Disease relevance of Glaphenine

• Anaphylaxis to glafenine [1].
• Diflunisal is comparable with glafenine in pain and with propoxyphene/paracetamol combinations and oxyphenbutazone in pain and in musculoskeletal strains and sprains [2].
• Leucocyte migration test and hypersensitivity to glafenin [3].
• Paracetamol, which has been shown to protect against the gastric erosive activity of aspirin, reduced the gastric toxicity of indomethacin but was ineffective against the erosive activity of phenylbutazone and glafenine [4].
• Recurrent acute renal failure due to nonaccidental poisoning with glafenin in a child [5].

High impact information on Glaphenine

• Compared with previously described techniques, this assay uses a very low glafenine linearity range, which allows the true pharmacokinetics of this drug to be described for the first time [6].
• The fluorescence properties of glafenine are partly caused by the anthranilic acid nucleus of the molecule [7].
• The methods are used for the study of glafenine purity, stability, bioavailability, bioequivalence and tablet dissolution rate [8].
• Mobile phases consisting of toluene-isopropyl alcohol-dimethylformamide-water (18:3:1:0.5) and methanol-water-phosphoric acid (80:120:0.5) are found to be efficient for reasonable separation and adequate resolution of glafenine from associated substances by thin layer chromatography (TLC) and HPLC techniques, respectively [8].
• Pharmacokinetic parameters were evaluated in 12 patients with alcoholic cirrhosis and 12 healthy volunteers after a single 400 mg oral dose of glafenine [9].

Chemical compound and disease context of Glaphenine

• 4. In the cases of probable anaphylaxis, the risk of anaphylaxis to glafenine relative to all other drugs was 167.7 in 1987 (95%-CI: 63.0-446.4) and 128.6 in 1988 (95%-CI: 50.4-328.5), to amoxycillin 15.2 in 1987 (95%-CI: 5.0-46.0) and 4.4 in 1988 (95%-CI: 1.03-18.9) and to diclofenac 6.1 in 1988 (95%-CI: 1.4-26.1).(ABSTRACT TRUNCATED AT 250 WORDS)[10]
• When given orally in elevated but nonlethal doses (150 to 450 mg/kg, on 2 consecutive days), glafenine induces in rats (body weight 100 g) a transient nephritis with an increase in blood urea, hypertrophy of adrenals, and some changes in the serum proteinogram [11].
• The pharmacological profile of glafenine, floctafenine and clometacine is characterized by a relatively strong effect on acetic acid writhing and a relatively weak effect on carrageenin oedema, U.V. erythema and adjuvant arthritis [12].

Biological context of Glaphenine

• Biotransformations of glafenine in the rat and in man [13].

Anatomical context of Glaphenine

• We report the analytical procedures for stone analysis in three cases of common bile duct stones containing glaphenic acid, which developed in arthrosic patients treated for 13.7 +/- 5 years with glaphenine [14].

Associations of Glaphenine with other chemical compounds

• Tiapride versus glafenine: a double-blind comparative study in the management of acute rheumatic pain [15].
• Double blind study of the effect of glafenine (Glifanan) on oral anticoagulant therapy with phenprocoumon (Marcumar) [16].
• The two drugs were found to have the same efficiency on the subjective parameters but high bioavailability glaphenine seems to have an effectiveness in the range of articulatory movements, which is not found with paracetamol [17].
• The bioavailability and gastric ulcerogenic activity of oxyphenbutazone and glafenine (acidic and basic nonsteroidal anti-inflammatory drugs), coated with different cellulose derivatives were assessed in albino rats [18].
• Simultaneous determination of glafenine and floctafenine in human plasma using high-performance liquid chromatography [19].

Gene context of Glaphenine

• This is an exceptional case of selective adverse reactions to glafenine and fenamates, anthranilic acid derivatives, in a patient tolerating aspirin and other cyclooxygenase inhibitors [20].

Analytical, diagnostic and therapeutic context of Glaphenine

• Determination of glafenine in dosage forms and serum by thin layer densitometry and high performance liquid chromatography [8].
• New thin layer densitometry and high performance liquid chromatography (HPLC) methods are described for quantitative determination of glafenine in dosage forms in the presence of its photo-degradation products and in serum in the presence of its metabolites [8].

References