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Chemical Compound Review

Diucardin     10,10-dioxo-4- (trifluoromethyl)-10$l^{6}...

Synonyms: Elodrine, Hydrenox, Leodrine, Olmagran, Rodiuran, ...
 
 
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Disease relevance of Trifluoromethylhydrothiazide

 

High impact information on Trifluoromethylhydrothiazide

 

Biological context of Trifluoromethylhydrothiazide

 

Anatomical context of Trifluoromethylhydrothiazide

 

Analytical, diagnostic and therapeutic context of Trifluoromethylhydrothiazide

  • Hydroflumethiazide plasma and urine levels were measured fluorometrically following the oral administration of 100-mg doses (2 X 50 mg tablets) to each of 12 healthy, adult male subjects [7].
  • Samples were purified by solvent extraction and analysed by reversed phase HPLC with ultraviolet detection, using hydroflumethiazide as the internal standard; plasma was eluted using gradient elution and urine was analysed isocratically [10].

References

  1. Hypertension in the elderly: review of therapy with a hydroflumethiazide-reserpine combination. Elkowitz, E.B. Journal of the American Geriatrics Society. (1979) [Pubmed]
  2. Fluorometric determination of hydroflumethiazide in human plasma and urine after its oral administration. Brors, O., Jacobsen, S., Arnesen, E. Eur. J. Clin. Pharmacol. (1977) [Pubmed]
  3. Pharmacokinetics of hydroflumethiazide during repeated administration in congestive heart failure. Brørs, O. Acta pharmacologica et toxicologica. (1982) [Pubmed]
  4. Absorption kinetics of hydroflumethiazide. McNamara, P.J., Colburn, W.A., Gibaldi, M. Journal of clinical pharmacology. (1978) [Pubmed]
  5. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Hermansen, K., Schmitz, O., Mogensen, C.E. Metab. Clin. Exp. (1985) [Pubmed]
  6. Mechanism of drug dissolution rate enhancement from beta-cyclodextrin-drug systems. Corrigan, O.I., Stanley, C.T. J. Pharm. Pharmacol. (1982) [Pubmed]
  7. Pharmacokinetics of orally administered hydroflumethiazide in man. Yakatan, G.J., Smith, R.B., Frome, E.L., Doluisio, J.T. Journal of clinical pharmacology. (1977) [Pubmed]
  8. Excretion of hydroflumethiazide in bile and urine of man. Brørs, O., Haffner, J.F., Jacobsen, S. Eur. J. Clin. Pharmacol. (1979) [Pubmed]
  9. Effect of thiazides on colonic NaCl absorption: role of carbonic anhydrase. Goldfarb, D.S., Chan, A.J., Hernandez, D., Charney, A.N. Am. J. Physiol. (1991) [Pubmed]
  10. Simple determination of hydrochlorothiazide in human plasma and urine by high performance liquid chromatography. de Vries, J.X., Voss, A. Biomed. Chromatogr. (1993) [Pubmed]
 
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