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Chemical Compound Review

PRBCM     2-(2-chloroethyl-propyl- amino)ethyl 2...

Synonyms: PrBCh, AC1L1XMW, C12H15ClNO2, LS-174586, 36167-80-3, ...
 
 
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Psychiatry related information on PROPYLBENZILYLCHOLINE MUSTARD

 

High impact information on PROPYLBENZILYLCHOLINE MUSTARD

 

Biological context of PROPYLBENZILYLCHOLINE MUSTARD

 

Anatomical context of PROPYLBENZILYLCHOLINE MUSTARD

  • To guide the formulation of the model itself and to define the various parameters, data were combined from assays performed under various conditions with native membranes and following irreversible blockade of about 80% of the receptors with propylbenzilylcholine mustard [8].
  • In order further to elucidate the role of muscarinic receptors in ganglionic transmission their distribution in the rat superior cervical sympathetic ganglion was investigated autoradiographically by use of the tritiated irreversible muscarinic ligand propylbenzilylcholine mustard [9].
  • Delivery of receptors to the plasma membrane was measured by irreversible alkylating receptors already at the cell surface with propylbenzilylcholine mustard (PrBCM) and then following the recovery of binding of the polar radioligand [3H]-N-methylscopolamine ([3H]-NMS) in intact cells [10].
  • In unanaesthetized cats the effects were examined of propylbenzilylcholine mustard (PrBCM) on injection into the cannulated cerebral ventricles and cisterna magna [11].
  • To test the hypothesis that the putative muscarinic receptor subtypes in rat forebrain are interconvertible states of the same receptor, the selective antagonist pirenzepine (PZ) was used to protect muscarinic receptors from blockade by the irreversible muscarinic receptor antagonist propylbenzilylcholine mustard (PBCM) [12].
 

Associations of PROPYLBENZILYLCHOLINE MUSTARD with other chemical compounds

 

Gene context of PROPYLBENZILYLCHOLINE MUSTARD

 

Analytical, diagnostic and therapeutic context of PROPYLBENZILYLCHOLINE MUSTARD

  • In order to determine whether a reserve population of either of these receptors is present in this cell culture, the irreversible muscarinic receptor antagonist, propylbenzilylcholine mustard (PBCM), was used at different concentrations to bind various proportions of available muscarinic receptors [18].
  • The characteristics of the putative subtypes of muscarinic receptors and their stimulation of phospholipase C was examined after treatment with two alkylating agents, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline and propylbenzilylcholine mustard [19].
  • The association of ATN afferents with muscarinic receptors was also explored by means of in vitro receptor autoradiography with the muscarinic ligands propylbenzilylcholine mustard (PrBCM) and pirenzepine (PZ) in normal rats and rats with ablations [20].

References

  1. Blockade of cholinergic receptors by an irreversible antagonist, propylbenzilylcholine mustard (PrBCM), in the rat cerebral cortex causes deficits in passive avoidance learning. Fukuchi, I., Kato, S., Nakahiro, M., Uchida, S., Ishida, R., Yoshida, H. Brain Res. (1987) [Pubmed]
  2. Experimental localization of muscarinic receptor subtypes to cingulate cortical afferents and neurons. Vogt, B.A., Burns, D.L. J. Neurosci. (1988) [Pubmed]
  3. Muscarinic cholinergic receptor structure. Receptor size, membrane orientation, and absence of major phylogenetic structural diversity. Venter, J.C. J. Biol. Chem. (1983) [Pubmed]
  4. Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas. Fisher, S.K., Snider, R.M. Mol. Pharmacol. (1987) [Pubmed]
  5. Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. Dunlap, J., Brown, J.H. Mol. Pharmacol. (1983) [Pubmed]
  6. Agarose gel keratinocyte outgrowth system as a model of skin re-epithelization: requirement of endogenous acetylcholine for outgrowth initiation. Grando, S.A., Crosby, A.M., Zelickson, B.D., Dahl, M.V. J. Invest. Dermatol. (1993) [Pubmed]
  7. Mechanism of soman-induced contractions in canine tracheal smooth muscle. Adler, M., Moore, D.H., Filbert, M.G. Arch. Toxicol. (1992) [Pubmed]
  8. Cardiac muscarinic receptors. Relationship between the G protein and multiple states of affinity. Green, M.A., Chidiac, P., Wells, J.W. Biochemistry (1997) [Pubmed]
  9. Autoradiographic localization of functional muscarinic receptors in the rat superior cervical sympathetic ganglion reveals an extensive distribution over non-synaptic surfaces of neuronal somata, dendrites and nerve endings. Ramcharan, E.J., Matthews, M.R. Neuroscience (1996) [Pubmed]
  10. Routes of delivery of muscarinic acetylcholine receptors to the plasma membrane in NG108-15 cells. Koenig, J.A., Edwardson, J.M. Br. J. Pharmacol. (1994) [Pubmed]
  11. Effects of propylbenzilylcholine mustard on injection into the liquor space of cats. Bergmann, F., Feldberg, W. Br. J. Pharmacol. (1978) [Pubmed]
  12. Muscarinic cholinergic receptor binding sites differentiated by their affinity for pirenzepine do not interconvert. Gil, D.W., Wolfe, B.B. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  13. Distance between the propylbenzilylcholine mustard attachment site and carbohydrates and thiol groups in muscarinic acetylcholine receptor protein from rat cerebral cortex. Alperin, D.M., Bouzat, C.B., Barrantes, F.J. Biochem. J. (1988) [Pubmed]
  14. Contrasting effects of carbachol, McN-A-343 and AHR-602 on Ca(2+)-mobilization and Ca(2+)-influx pathways in taenia caeci. Hishinuma, S., Hongo, I., Matsumoto, Y., Narita, F., Kurokawa, M. Br. J. Pharmacol. (1997) [Pubmed]
  15. Guanosine 5'-triphosphate converts some populations of propylbenzilylcholine mustard-sensitive muscarinic cholinoceptor sites to sites resistant to the drug in intestinal smooth muscle. Kiuchi, Y., Kumagai, N., Hisayama, T., Takayanagi, I. Jpn. J. Pharmacol. (1991) [Pubmed]
  16. Modification of cholinergic-mediated cellular transmembrane signals by the interaction of human chagasic IgG with cardiac muscarinic receptors. Goin, J.C., Perez Leiros, C., Borda, E., Sterin-Borda, L. Neuroimmunomodulation (1994) [Pubmed]
  17. Irreversible and quaternary muscarinic antagonists discriminate multiple muscarinic receptor binding sites in rat brain. Norman, A.B., Eubanks, J.H., Creese, I. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  18. Propylbenzilylcholine mustard has greater specificity for muscarinic m2 receptors than for m3 receptors present in cerebellar granule cell culture from rat. McLeskey, S.W., Wojcik, W.J. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  19. Differential effects of alkylating agents on the multiple muscarinic receptor subtypes linked to activation of phospholipase C by carbachol in rat brain cortical membranes. Sallés, J., Wallace, M.A., Fain, J.N. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  20. Afferent connections of anterior thalamus in rats: sources and association with muscarinic acetylcholine receptors. Sikes, R.W., Vogt, B.A. J. Comp. Neurol. (1987) [Pubmed]
 
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