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Chemical Compound Review:

PCDD 54 1,2,3,7,8- pentachlorooxanthrene

Synonyms: CHEMBL137220, SureCN2885718, LS-1251, KST-1B0045, CTK8I6034, ...

Gao, X. et al., Maruyama, W. et al., Okuyama, M. et al., De Jongh, J. et al.

Maruyama, Aoki,

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Disease relevance of BRN 1626844

Previous studies have shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), and 1,2,3,4,7, 8-hexachlorodibenzo-p-dioxin (HxCDD), and their equipotent mixture block ovulation, reduce ovarian weight gain and alter preovulatory hormone levels in a similar manner [1].
To quantify the toxicity of a mixture of three dioxin congeners, we calculated the new relative potencies (REPs) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), and 2,3,4,7,8- pentachlorodibenzofuran (PeCDF), focusing on their tumor promotion activity [2].

High impact information on BRN 1626844

After five fusion experiments, a hybridoma clone was established that secretes an antibody D9-36 group specifically recognizing the major toxic congeners, 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin, and 2,3,4,7,8-pentachlorodibenzofran [3].
Interactions between 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PnCDD) and 2,4,5,2',4',5'-hexachlorobiphenyl (HxCB) on hepatic retention of PnCDD and on cytochrome P450 related enzyme activities were studied in male C57BL/6J mice [4].

References

Effects of polychlorinated dibenzofurans, biphenyls, and their mixture with dibenzo-p-dioxins on ovulation in the gonadotropin-primed immature rat: support for the toxic equivalency concept. Gao, X., Terranova, P.F., Rozman, K.K. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
Estimated cancer risk of dioxins to humans using a bioassay and physiologically based pharmacokinetic model. Maruyama, W., Aoki, Y. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
Enzyme-linked immunosorbent assay for monitoring toxic dioxin congeners in milk based on a newly generated monoclonal anti-dioxin antibody. Okuyama, M., Kobayashi, N., Takeda, W., Anjo, T., Matsuki, Y., Goto, J., Kambegawa, A., Hori, S. Anal. Chem. (2004) [Pubmed]
Absence of interactions on hepatic retention and 7-ethoxyresorufin-O-deethylation activity after co-administration of 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 2,4,5,2',4',5'-hexachlorobiphenyl. De Jongh, J., Wondergem, F., Seinen, W., Van den Berg, M. Toxicology (1992) [Pubmed]

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