Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L8XA0 3,5,7,8,9- pentazabicyclo[4.3.0]nona- 3,5,8...

Synonyms: 8-AZHYPOXANTHINE, 7aH-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol, 3,7a-dihydrotriazolo[4,5-d]pyrimidin-7-one

Moore, B.C. et al., Takimoto, T. et al.

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High impact information on AE 200

The technique uses a negative selection strategy that takes advantage of the ability of the M. maripaludis hpt gene encoding hypoxanthine phosphoribosyltransferase to confer sensitivity to the base analog 8-azahypoxanthine [1].
An epithelial-like hybrid cell line was established by cell fusion of 8-azahypoxanthine-resistant epithelial cells (Ad-AH) with lymphoblastoid cells (A2L), derived from the human nasopharynx [2].

References

Markerless mutagenesis in Methanococcus maripaludis demonstrates roles for alanine dehydrogenase, alanine racemase, and alanine permease. Moore, B.C., Leigh, J.A. J. Bacteriol. (2005) [Pubmed]
Epstein-Barr virus nuclear antigen-positive nasopharyngeal hybrid cells. Takimoto, T., Furukawa, M., Hatano, M., Umeda, R. The Annals of otology, rhinology, and laryngology. (1984) [Pubmed]

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