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Chemical Compound Review

AC1L92T5     6-methoxy-5H-purin-2-amine

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Disease relevance of O6-Methylguanine


Psychiatry related information on O6-Methylguanine


High impact information on O6-Methylguanine


Chemical compound and disease context of O6-Methylguanine


Biological context of O6-Methylguanine


Anatomical context of O6-Methylguanine


Associations of O6-Methylguanine with other chemical compounds


Gene context of O6-Methylguanine


Analytical, diagnostic and therapeutic context of O6-Methylguanine


  1. Mismatch correction at O6-methylguanine residues in E. coli DNA. Karran, P., Marinus, M.G. Nature (1982) [Pubmed]
  2. Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines. Sklar, R., Strauss, B. Nature (1981) [Pubmed]
  3. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. Friedman, H.S., Dolan, M.E., Moschel, R.C., Pegg, A.E., Felker, G.M., Rich, J., Bigner, D.D., Schold, S.C. J. Natl. Cancer Inst. (1992) [Pubmed]
  4. Deficient repair of DNA lesion O6-methylguanine in cirrhosis. Collier, J.D., Guo, K., Burt, A.D., Bassendine, M.F., Major, G.N. Lancet (1993) [Pubmed]
  5. uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174. Chambers, R.W., Sledziewska-Gojska, E., Hirani-Hojatti, S., Borowy-Borowski, H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  6. O6-methylguanine-DNA methyltransferase in human fetal tissues: fetal and maternal factors. D'Ambrosio, S.M., Samuel, M.J., Dutta-Choudhury, T.A., Wani, A.A. Cancer Res. (1987) [Pubmed]
  7. Mechanism of mutagenesis by O6-methylguanine. Eadie, J.S., Conrad, M., Toorchen, D., Topal, M.D. Nature (1984) [Pubmed]
  8. Time course of O6-methylguanine removal from DNA of N-methyl-N-nitrosourea-treated human fibroblasts. Medcalf, A.S., Lawley, P.D. Nature (1981) [Pubmed]
  9. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Erickson, L.C., Laurent, G., Sharkey, N.A., Kohn, K.W. Nature (1980) [Pubmed]
  10. Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA. Kleihues, P., Margison, G.P. Nature (1976) [Pubmed]
  11. Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. Lindahl, T., Demple, B., Robins, P. EMBO J. (1982) [Pubmed]
  12. Repair of O6-methylguanine in adapted Escherichia coli. Schendel, P.F., Robins, P.E. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  13. Estrous cycle modification of rat mammary gland DNA alkylation by N-methyl-N-nitrosourea. Ratko, T.A., Braun, R.J., Pezzuto, J.M., Beattie, C.W. Cancer Res. (1988) [Pubmed]
  14. Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base. Yarosh, D.B., Hurst-Calderone, S., Babich, M.A., Day, R.S. Cancer Res. (1986) [Pubmed]
  15. Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase. Gerson, S.L., Trey, J.E., Miller, K. Cancer Res. (1988) [Pubmed]
  16. Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels. Pegg, A.E. J. Natl. Cancer Inst. (1977) [Pubmed]
  17. DNA alkylation and tumor induction in regenerating rat liver after cell cycle-related continuous N-nitrosodimethylamine infusion. Rabes, H.M., Kerler, R., Wilhelm, R. J. Natl. Cancer Inst. (1983) [Pubmed]
  18. Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase. Ellison, K.S., Dogliotti, E., Connors, T.D., Basu, A.K., Essigmann, J.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  19. Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct. Duckett, D.R., Drummond, J.T., Murchie, A.I., Reardon, J.T., Sancar, A., Lilley, D.M., Modrich, P. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  20. Extracts of chronic lymphocytic leukemia lymphocytes have a high level of DNA repair activity fo O6-methylguanine. Waldstein, E.A., Cao, E.H., Miller, M.E., Cronkite, E.P., Setlow, R.B. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  21. Regulation of the capacity for O6-methylguanine removal from DNA in human lymphoblastoid cells studied by cell hybridization. Ayres, K., Sklar, R., Larson, K., Lindgren, V., Strauss, B. Mol. Cell. Biol. (1982) [Pubmed]
  22. O6-Methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual. Sklar, R.M., Strauss, B.S. Cancer Res. (1983) [Pubmed]
  23. Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair. Souliotis, V.L., Kaila, S., Boussiotis, V.A., Pangalis, G.A., Kyrtopoulos, S.A. Cancer Res. (1990) [Pubmed]
  24. Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents. Dolan, M.E., Young, G.S., Pegg, A.E. Cancer Res. (1986) [Pubmed]
  25. Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid. Dixit, R., Gold, B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  26. Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes. Mitra, G., Pauly, G.T., Kumar, R., Pei, G.K., Hughes, S.H., Moschel, R.C., Barbacid, M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  27. Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine. Williams, L.D., Shaw, B.R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Hirose, Y., Berger, M.S., Pieper, R.O. Cancer Res. (2001) [Pubmed]
  29. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. Kaina, B., Ochs, K., Grösch, S., Fritz, G., Lips, J., Tomicic, M., Dunkern, T., Christmann, M. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  30. A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae. Xiao, W., Singh, K.K., Chen, B., Samson, L. Mol. Cell. Biol. (1993) [Pubmed]
  31. Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum. Sandercock, L.E., Kwok, M.C., Luchman, H.A., Mark, S.C., Giesbrecht, J.L., Samson, L.D., Jirik, F.R. Oncogene (2004) [Pubmed]
  32. Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Roos, W., Baumgartner, M., Kaina, B. Oncogene (2004) [Pubmed]
  33. Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis. Fukushima, S. Mutat. Res. (2001) [Pubmed]
  34. Modulation of nitrosourea resistance in myeloid leukemias. Gerson, S.L., Trey, J.E. Blood (1988) [Pubmed]
  35. Cell specificity in hepatocarcinogenesis: preferential accumulation of O6-methylguanine in target cell DNA during continuous exposure to rats to 1,2-dimethylhydrazine. Bedell, M.A., Lewis, J.G., Billings, K.C., Swenberg, J.A. Cancer Res. (1982) [Pubmed]
  36. Highly sensitive, specific detection of O6-methylguanine, O4-methylthymine, and O4-ethylthymine by the combination of high-performance liquid chromatography prefractionation, 32P postlabeling, and immunoprecipitation. Kang, H.I., Konishi, C., Eberle, G., Rajewsky, M.F., Kuroki, T., Huh, N.H. Cancer Res. (1992) [Pubmed]
  37. Nondetection of O6-methylguanine in rat DNA following in vivo treatment with large doses of cimetidine alone or in combination with sodium nitrite. Kyrtopoulos, S.A., Hadjiloucas, E., Vrotsou, B. Cancer Res. (1982) [Pubmed]
  38. Immunological detection of O6-methylguanine in alkylated DNA. Briscoe, W.T., Spizizen, J., Tan, E.M. Biochemistry (1978) [Pubmed]
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