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Chemical Compound Review:

AC1N53XV dimethylcarbamate

Synonyms: N,N-Dimethylcarbamate

This record was replaced with 44946.

Prester, L. et al., Simeon-Rudolf, V. et al., Kitson, T.M., Kovarik, Z. et al.

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High impact information on dimethylcarbamic acid

The effect of PNP dimethylcarbamate on the dehydrogenase activity of the enzyme is consistent with there being a single type of active site for the enzyme's dehydrogenase and esterase activities [1].
Kinetics of the inhibition of human serum cholinesterase phenotypes with the dimethylcarbamate of (2-hydroxy-5-phenylbenzyl)-trimethylammonium bromide (Ro 02-0683) [2].
The time course of inhibition of butyrylcholinesterase (EC 3.1.1.8) by the dimethylcarbamate Ro 02-0683 in sera taken from patients heterozygous for the usual (U), atypical (A), K or J variants was followed using propionylthiocholine as substrate [3].
Bambuterol, a dimethylcarbamate, carbamoylates butyrylcholinesterase (BChE; EC 3.1.1.8) [4].

Biological context of dimethylcarbamic acid

The three phenotypes could be distinguished by the rate of inhibition by the dimethylcarbamate, Ro 02-0683, in the progressive phase of inhibition or by the degree of inhibition in the apparent steady-state [2].

References

The action of cytoplasmic aldehyde dehydrogenase on methyl p-nitrophenyl carbonate and p-nitrophenyl dimethylcarbamate. Kitson, T.M. Biochem. J. (1989) [Pubmed]
Kinetics of the inhibition of human serum cholinesterase phenotypes with the dimethylcarbamate of (2-hydroxy-5-phenylbenzyl)-trimethylammonium bromide (Ro 02-0683). Prester, L., Simeon, V. Biochem. Pharmacol. (1991) [Pubmed]
An explanation for the different inhibitory characteristics of human serum butyrylcholinesterase phenotypes deriving from inhibition of atypical heterozygotes. Simeon-Rudolf, V., Kovarik, Z., Skrinjarić-Spoljar, M., Evans, R.T. Chem. Biol. Interact. (1999) [Pubmed]
Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline. Kovarik, Z., Simeon-Rudolf, V. Journal of enzyme inhibition and medicinal chemistry. (2004) [Pubmed]

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