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Chemical Compound Review:

Talisomycin [2-[2-[2-[[6-amino-2-[1-[(2- amino-2...

Synonyms: TALLYSOMYCIN, Tallysomycin A, NSC-279496, NSC279496, AC1L8PP9, ...

Kawaguchi, H. et al., Demopoulos, N.A. et al., Tao, M. et al., Worth, L. et al., Newman, R.A. et al., et al.

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Disease relevance of BLEOMYCIN ANALOG

Assessment of bleomycin-, tallysomycin-, and polyamine-mediated acute lung toxicity by pulmonary lavage angiotensin-converting enzyme activity [1].
Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice [2].
The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2) [2].
Uptake of labelled tallysomycin by solid Ehrlich ascites tumors in mice [3].

High impact information on BLEOMYCIN ANALOG

However, the isotope effect is sensitive to structural changes in BLM, such as with tallysomycin, and to changes in metal and cleavage mechanism, such as with Co.BLM [4].
We have investigated the genetic activity of tallysomycin in the ascomycete Aspergillus nidulans for malsegregation of chromosomes at mitosis and for point mutations [5].
Tallysomycin-induced mitotic aneuploidy and point mutations in Aspergillus nidulans [5].
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics [6].
Pharmacokinetics of tallysomycin and bleomycin in the beagle dog [7].

Analytical, diagnostic and therapeutic context of BLEOMYCIN ANALOG

A radioimmunoassay for tallysomycin [8].

References

Assessment of bleomycin-, tallysomycin-, and polyamine-mediated acute lung toxicity by pulmonary lavage angiotensin-converting enzyme activity. Newman, R.A., Hacker, M.P., Kimberly, P.J., Braddock, J.M. Toxicol. Appl. Pharmacol. (1981) [Pubmed]
Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties. Kawaguchi, H., Tsukiura, H., Tomita, K., Konishi, M., Saito, K. J. Antibiot. (1977) [Pubmed]
Uptake of labelled tallysomycin by solid Ehrlich ascites tumors in mice. Liniecki, J., Rembelska, M., Koniarek, B. Nuklearmedizin. (1983) [Pubmed]
Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. Worth, L., Frank, B.L., Christner, D.F., Absalon, M.J., Stubbe, J., Kozarich, J.W. Biochemistry (1993) [Pubmed]
Tallysomycin-induced mitotic aneuploidy and point mutations in Aspergillus nidulans. Demopoulos, N.A., Kappas, A. Mutagenesis (1986) [Pubmed]
The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Tao, M., Wang, L., Wendt-Pienkowski, E., George, N.P., Galm, U., Zhang, G., Coughlin, J.M., Shen, B. Molecular bioSystems (2007) [Pubmed]
Pharmacokinetics of tallysomycin and bleomycin in the beagle dog. Strong, J.E., Schurig, J.E., Issell, B.F., Kramer, W.G., Tavel, A.F., Florczyk, A.P., Crooke, S.T. Cancer treatment reports. (1979) [Pubmed]
A radioimmunoassay for tallysomycin. Broughton, A., Strong, J.E., Crooke, S.T., Prestayko, A.W., Knight, J. Cancer treatment reports. (1979) [Pubmed]

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