Disease relevance of Pamatolol

• The species variation between the mouse and the rat with regard to long-term toxicity of pamatolol is discussed [1].

High impact information on Pamatolol

• Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker [2].
• There was a clear relationship between log plasma pamatolol concentration and sympathetic blockade assessed by reduction of exercise heart rate [2].
• The systemic bioavailability, elimination half-life (t1/2), and plasma concentration--response relationships of pamatolol, a relatively cardioselective beta adrenoceptor blocker, have been measured in healthy subjects [2].
• Neither resting systolic time intervals nor post-exercise pulmonary function was affected by this dose range of pamatolol [3].

Analytical, diagnostic and therapeutic context of Pamatolol

• The metabolism of pamatolol was studied in man, dogs, rats and mice after oral administration of a single dose [1].

References