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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

mevalonate     (3R)-3,5-dihydroxy-3-methyl- pentanoic acid

Synonyms: mevalonic acid, CHEMBL1794734, CHEBI:17710, CTK0E3502, LMFA01050352, ...
 
 
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High impact information on mevalonic acid

  • Studies were carried out in humans and in rhesus monkeys to determine the role of the kidneys in the metabolism of circulating mevalonic acid (MVA) [1].
  • RESULTS: Urinary MVA excretion rates (mumol/24h) were 1.82 +/- 0.21 in control subjects and 2.49 +/- 0.35 (P < 0.01 vs. control subjects) and 1.78 +/- 0.28 in patients before and after intensive insulin therapy, respectively [2].
  • LDL apheresis of 75% of the calculated plasma volume reduced LDL-cholesterol by 44% to 1.5 +/- 0.2 mmol/l without changing plasma MVA levels or L/C ratios [3].
  • A significant positive correlation was found between percentage decrease of MVA and non-esterified fatty acids following the insulin clamp in NIDDM (r = 0.83, P = 0.04) [4].
  • There was a highly significant positive correlation between ASR of VLDL apoB and plasma MVA (r = .88, P = .004), which persisted after adjusting for apo E phenotype [5].
 

Analytical, diagnostic and therapeutic context of mevalonic acid

  • Acute insulin infusion during the euglycemic clamp studies reduced mean plasma MVA concentrations at 120 and 180 min by 29 and 38%, respectively (P < 0.01 for both vs. baseline) [2].

References

  1. Role of the kidneys in the metabolism of plasma mevalonate. Studies in humans and in rhesus monkeys. McNamara, D.J., Ahrens, E.H., Parker, T.S., Morrissey, K. J. Clin. Invest. (1985) [Pubmed]
  2. Effects of insulin on cholesterol synthesis in type II diabetes patients. Scoppola, A., Testa, G., Frontoni, S., Maddaloni, E., Gambardella, S., Menzinger, G., Lala, A. Diabetes Care (1995) [Pubmed]
  3. Upregulation of cholesterol synthesis after acute reduction of low density lipoprotein by apheresis in normocholesterolaemic subjects: evidence for a threshold effect. Pfohl, M., Naoumova, R.P., Neuwirth, C., Sussekov, A., Smykowski, J., Rendell, N.B., Taylor, G.W., Seif, F.J., Thompson, G.R. Atherosclerosis (1997) [Pubmed]
  4. Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insulin-dependent diabetes mellitus than in non-diabetic subjects. Naoumova, R.P., Cummings, M.H., Watts, G.F., Rendell, N.B., Taylor, G.W., Sönksen, P.H., Thompson, G.R. Eur. J. Clin. Invest. (1996) [Pubmed]
  5. Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects. Watts, G.F., Naoumova, R., Cummings, M.H., Umpleby, A.M., Slavin, B.M., Sönksen, P.H., Thompson, G.R. Metab. Clin. Exp. (1995) [Pubmed]
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