Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CoA S-acrylate [(2R,3S,4R,5R)-5-(6- aminopurin-9-yl)-4...

Synonyms: AG-G-04049, HMDB02307, CTK5A7395, AC1L975Z, 5776-58-9, ...

Baker-Malcolm, J.F. et al., Fitzsimmons, M.E. et al., Hetzel, M. et al., Seeliger, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Acrylyl-CoA

Acryloyl-CoA reductase from Clostridium propionicum catalyses the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA [1].

High impact information on Acrylyl-CoA

This paper shows that DCTFTH-CoA can be directly bioactivated by the enoyl-CoA hydratase (ECH) with the release of 1,2-dichloro-3,3,3-trifluoro-1-propenethiolate and acryloyl-CoA [2].
The medium-chain acyl-CoA dehydrogenase was not inactivated by acryloyl-CoA, and little inactivation was observed in the presence of FcPF6 [3].
Energetics and kinetics of lactate fermentation to acetate and propionate via methylmalonyl-CoA or acrylyl-CoA [4].

References

Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein. Hetzel, M., Brock, M., Selmer, T., Pierik, A.J., Golding, B.T., Buckel, W. Eur. J. Biochem. (2003) [Pubmed]
Novel inactivation of enoyl-CoA hydratase via beta-elimination of 5, 6-dichloro-7,7,7-trifluoro-4-thia-5-heptenoyl-CoA. Baker-Malcolm, J.F., Lantz, M., Anderson, V.E., Thorpe, C. Biochemistry (2000) [Pubmed]
Medium-chain acyl-CoA dehydrogenase- and enoyl-CoA hydratase-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoyl-CoA. Fitzsimmons, M.E., Thorpe, C., Anders, M.W. Biochemistry (1995) [Pubmed]
Energetics and kinetics of lactate fermentation to acetate and propionate via methylmalonyl-CoA or acrylyl-CoA. Seeliger, S., Janssen, P.H., Schink, B. FEMS Microbiol. Lett. (2002) [Pubmed]

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