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Chemical Compound Review:

AG-F-00826 2-(aminocarbonyl-methyl- amino)ethanoic acid

Synonyms: CHEBI:15737, HMDB12265, CTK8F2278, AKOS009043765, AC1L9788, ...

Kim, J.M. et al., Zajc, A. et al., Romão, M.J. et al., Hermann, M. et al., Kim, J.M. et al.

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Disease relevance of N-Carbamoylsarcosine

Purification and characterization of a novel enzyme, N-carbamoylsarcosine amidohydrolase, from Pseudomonas putida 77 [1].
Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution [2].
These strains, named Clostridium sp. FS23 and Clostridium sp. FS41, totally degraded NMH, via N-carbamoylsarcosine (CS) and sarcosine as intermediates [3].

High impact information on N-Carbamoylsarcosine

Crystal structures of N-carbamoylsarcosine amidohydrolase (CSHase; EC 3.5.1.59) have been analyzed by X-ray diffraction methods with two different inhibitors bound to the active site at 2.28 A and 2.37 A resolution [4].
A new enzyme, N-methylhydantoin amidohydrolase, was highly purified from Pseudomonas putida 77: it catalyzes the hydrolysis of N-methylhydantoin to N-carbamoylsarcosine with the concomitant stoichiometric cleavage of ATP to ADP and orthophosphate [5].

References

Purification and characterization of a novel enzyme, N-carbamoylsarcosine amidohydrolase, from Pseudomonas putida 77. Kim, J.M., Shimizu, S., Yamada, H. J. Biol. Chem. (1986) [Pubmed]
Crystal structure analysis, refinement and enzymatic reaction mechanism of N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. at 2.0 A resolution. Romão, M.J., Turk, D., Gomis-Rüth, F.X., Huber, R., Schumacher, G., Möllering, H., Rüssmann, L. J. Mol. Biol. (1992) [Pubmed]
Creatinine and N-methylhydantoin degradation in two newly isolated Clostridium species. Hermann, M., Knerr, H.J., Mai, N., Gross, A., Kaltwasser, H. Arch. Microbiol. (1992) [Pubmed]
Crystallographic and fluorescence studies of ligand binding to N-carbamoylsarcosine amidohydrolase from Arthrobacter sp. Zajc, A., Romão, M.J., Turk, B., Huber, R. J. Mol. Biol. (1996) [Pubmed]
Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis. Kim, J.M., Shimizu, S., Yamada, H. Biochem. Biophys. Res. Commun. (1987) [Pubmed]

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