Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN851399 [(2R,3S,4R,5R)-5-(2,4-dioxo- 1H-pyrimidin-5...

Synonyms: CHEBI:18116, HMDB01271, AC1L97BN, C01168, 1157-60-4, ...

Shibata, H. et al., Carbon, P. et al., Matsumoto, K. et al.

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High impact information on Pseudouridylic acid

With yeast tRNA-Asp-GUC, we have replaced one or several nucleotides in the vicinity of G34 by one of the four canonical nucleotides or by pseudouridylic acid; we have also constructed a tRNAAsp with eight bases instead of seven in the anticodon loop [1].
The nuclear U-2 RNA which is highly modified (Reddy, R., Ro Choi, T.S., Henning, D., Shibata, H., Choi, Y.C., and Busch H. (1972) J. Biol. Chem. 247, 7245-7250) contains 13 pseudouridylic acid residues, 10 2'-O-methylated nucleotides and two modified bases including N-2,2, 7-trimethyl guanylic acid in its 5'-terminal portion (69 nucleotides) [2].
The pseudouridylic acid residues are located in specific oligonucleotides and each of the modified nucleotides amounts to 0.5 to 1.0 mol per mol of RNA [3].

References

Site-directed in vitro replacement of nucleosides in the anticodon loop of tRNA: application to the study of structural requirements for queuine insertase activity. Carbon, P., Haumont, E., Fournier, M., de Henau, S., Grosjean, H. EMBO J. (1983) [Pubmed]
The primary nucleotide sequence of nuclear U-2 ribonucleic acid. The 5'-terminal portion of the molecule. Shibata, H., Ro-Choi, T.S., Reddy, R., Choi, Y.C., Henning, D., Busch, H. J. Biol. Chem. (1975) [Pubmed]
Pseudouridylic modification of a 6S RNA transcribed in vitro from highly repetitive and transcribable (Hirt) sequences of salmon total DNA. Matsumoto, K., Murakami, K., Okada, N. Biochem. Biophys. Res. Commun. (1984) [Pubmed]

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