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Chemical Compound Review:

Galactinol (1R,2S,4R,5R)-6- [(2S,3R,4S,5R,6R)-3,4,5...

Synonyms: SureCN1977920, SureCN7127589, HMDB05826, AC1L97DN, 1-alpha-D-Galactosyl-myo-inositol, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C01235

All the GST fusion proteins of GST-AtGolS1, 2 and 3 expressed in Escherichia coli had galactinol synthase activities [1].

High impact information on C01235

In the HsfA2-overexpressing Arabidopsis (Pro(35S):HsfA2) plants, 46 genes, including a large number of heat-shock proteins, ascorbate peroxidase 2 and galactinol synthase 1 and 2, were highly expressed compared with those in the wild-type plants [2].
Significant increases in galactinol synthase and alternative oxidase after salt shock and salt adaptation point to shifts in carbohydrate metabolism and suppression of reactive oxygen species in mitochondria under salt stress [3].
A galactinol synthase promoter from melon drives gene expression in the minor-vein companion cells of both transgenic tobacco (Nicotiana tabacum) and Arabidopsis [4].
Sugar analysis showed that drought-, high salinity- and cold-treated Arabidopsis plants accumulate a large amount of raffinose and galactinol, but not stachyose [1].

Analytical, diagnostic and therapeutic context of C01235

Expression of a GALACTINOL SYNTHASE gene in tomato seeds is up-regulated before maturation desiccation and again after imbibition whenever radicle protrusion is prevented [5].
The product was identified as galactinol by the retention times of HPLC, alpha-galactosidase digestion, and NMR spectrometry [6].

References

Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana. Taji, T., Ohsumi, C., Iuchi, S., Seki, M., Kasuga, M., Kobayashi, M., Yamaguchi-Shinozaki, K., Shinozaki, K. Plant J. (2002) [Pubmed]
Arabidopsis heat shock transcription factor A2 as a key regulator in response to several types of environmental stress. Nishizawa, A., Yabuta, Y., Yoshida, E., Maruta, T., Yoshimura, K., Shigeoka, S. Plant J. (2006) [Pubmed]
Populus euphratica displays apoplastic sodium accumulation, osmotic adjustment by decreases in calcium and soluble carbohydrates, and develops leaf succulence under salt stress. Ottow, E.A., Brinker, M., Teichmann, T., Fritz, E., Kaiser, W., Brosché, M., Kangasjärvi, J., Jiang, X., Polle, A. Plant Physiol. (2005) [Pubmed]
Functional and phylogenetic analyses of a conserved regulatory program in the phloem of minor veins. Ayre, B.G., Blair, J.E., Turgeon, R. Plant Physiol. (2003) [Pubmed]
Expression of a GALACTINOL SYNTHASE gene in tomato seeds is up-regulated before maturation desiccation and again after imbibition whenever radicle protrusion is prevented. Downie, B., Gurusinghe, S., Dahal, P., Thacker, R.R., Snyder, J.C., Nonogaki, H., Yim, K., Fukanaga, K., Alvarado, V., Bradford, K.J. Plant Physiol. (2003) [Pubmed]
Production of galactinol from sucrose by plant enzymes. Wakiuchi, N., Shiomi, R., Tamaki, H. Biosci. Biotechnol. Biochem. (2003) [Pubmed]

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