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Chemical Compound Review

CHEMBL1269805     (2S)-2-[[(2S)-2-[[(2S)-2- amino-5...

Synonyms: AC1L97OK, C01952, Poly-L-arginine
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Disease relevance of C01952


High impact information on C01952


Chemical compound and disease context of C01952


Biological context of C01952


Anatomical context of C01952


Associations of C01952 with other chemical compounds

  • Similarly, leukocyte desensitization also inhibited histamine release induced by anti-IgE but not by formyl-L-methionyl-L-leucyl-L-phenylalanine or poly-L-arginine [20].
  • 4. In vitro capsaicin-induced desensitization failed to attenuate the contractile response to poly-L-arginine, suggesting little, if any role for sensory neuropeptides in the functional response in the guinea-pig [21].
  • Variable temperature circular dichroism (CD) and gel electrophoresis results revealed that the association and dissociation of PNIPArg/DNA complexes could be tuned by varying temperature; polyarginine (PArg) showed no temperature-controllable change of DNA condensate [22].
  • In contrast, when the serosal surface of the trachea was treated with poly-L-arginine, there was no modification of either methacholine-induced contraction or KCl-induced relaxation [23].
  • In the present study, mixed liposomes of dihexadecyl phosphate sodium salt:phosphatidylcholine:cholesterol at a 1:19:9.5 molar ratio were allowed to interact with poly-L-arginine at temperatures below and above the main phase transition of the liposomal membrane [24].

Gene context of C01952

  • In agreement with observations previously reported for CAP37, the LPS-enhancing effect of poly-L-arginine was completely abolished upon antibody blockade of the human LPS receptor, CD14 [25].
  • In contrast, heating had no effect on the cytotoxic effects of protamine or poly-L-arginine [26].
  • In order to gain information on the mechanism by which NO2 damages the lung and proteins vital to its function, as well as its reaction with proteins in general, in vitro exposures of alpha-1-proteinase inhibitor (alpha 1PI), elastin, poly-L-lysine, and poly-L-arginine were performed [27].
  • Exposure of mTAL cells to either Ca(o)(2+) or the CaR-selective agonist poly-L-arginine increased TNF-alpha synthesis [28].
  • Challenge with the CaR-selective agonist poly-L-arginine (PLA) also increased COX-2 mRNA accumulation, protein expression, and PGE(2) synthesis [29].

Analytical, diagnostic and therapeutic context of C01952


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  18. Cationic proteins inhibit L-arginine uptake in rat alveolar macrophages and tracheal epithelial cells. Implications for nitric oxide synthesis. Hammermann, R., Hirschmann, J., Hey, C., Mössner, J., Folkerts, G., Nijkamp, F.P., Wessler, I., Racké, K. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  19. Suppression of maxi-K channel and membrane depolarization by synthetic polycations in single tracheal myocytes. Oshiro, T., Sasaki, T., Nara, M., Tamada, T., Shimura, S., Maruyama, Y., Shirato, K. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  20. Adverse reactions to suxamethonium and other muscle relaxants under general anesthesia. Vervloet, D., Nizankowska, E., Arnaud, A., Senft, M., Alazia, M., Charpin, J. J. Allergy Clin. Immunol. (1983) [Pubmed]
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  23. Cationic proteins alter smooth muscle function by an epithelium-dependent mechanism. Coyle, A.J., Mitzner, W., Irvin, C.G. J. Appl. Physiol. (1993) [Pubmed]
  24. Interaction of poly-L-arginine with dihexadecyl phosphate/phosphatidylcholine liposomes. Tsogas, I., Tsiourvas, D., Nounesis, G., Paleos, C.M. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
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  27. Nitrogen dioxide reactivity with proteins: effects on activity and immunoreactivity with alpha-1-proteinase inhibitor and implications for NO2-mediated peptide degradation. Hood, D.B., Gettins, P., Johnson, D.A. Arch. Biochem. Biophys. (1993) [Pubmed]
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  29. CaR-mediated COX-2 expression in primary cultured mTAL cells. Wang, D., An, S.J., Wang, W.H., McGiff, J.C., Ferreri, N.R. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  30. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma. Zhang, S., Smartt, H., Holgate, S.T., Roche, W.R. Lab. Invest. (1999) [Pubmed]
  31. Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats. Hayashi, K., Sato, H., Kaise, T., Ohmori, K., Ishii, A., Sano, J., Karasawa, A. Eur. J. Pharmacol. (2001) [Pubmed]
  32. Effects of the cationic protein poly-L-arginine on airway epithelial cells in vitro. Shahana, S., Kampf, C., Roomans, G.M. Mediators of inflammation. (2002) [Pubmed]
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