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Chemical Compound Review:

AC1L98J3 [(2R,3R)-2,3,4- trihydroxybutoxy]phosphonic...

Synonyms:

Okada, K. et al., Nagata, N. et al., Terada, T. et al.

Okada, Kawaide, Kuzuyama, Seto, Curtis, Kamiya,

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High impact information on C03494

(ecotype Columbia) expressing the antisense AtMECT gene, encoding 2- C-methyl- D-erythritol 4-phosphate cytidylyltransferase, were generated to elucidate the physiological role of the nonmevalonate pathway for production of ent-kaurene, the latter being the plastidic precursor of gibberellins [1].
Isopentenyl diphosphate (IPP) is produced via two independent biosynthetic pathways in higher plants: the mevalonate (MVA) pathway in the cytoplasm and the non-mevalonate 2-C-methyl- D-erythritol-4-phosphate (MEP) pathway in plastids [2].
An aldehyde reductase catalyzing the NADPH-dependent reduction of D-erythrose 4-phosphate to D-erythritol 4-phosphate was purified from beef liver [3].

References

Antisense and chemical suppression of the nonmevalonate pathway affects ent-kaurene biosynthesis in Arabidopsis. Okada, K., Kawaide, H., Kuzuyama, T., Seto, H., Curtis, I.S., Kamiya, Y. Planta (2002) [Pubmed]
Mevalonic acid partially restores chloroplast and etioplast development in Arabidopsis lacking the non-mevalonate pathway. Nagata, N., Suzuki, M., Yoshida, S., Muranaka, T. Planta (2002) [Pubmed]
Purification and properties of beef liver aldehyde reductase catalyzing the reduction of D-erythrose 4-phosphate. Terada, T., Kohno, T., Samejima, T., Hosomi, S., Mizoguchi, T., Uehara, K. J. Biochem. (1985) [Pubmed]

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