Disease relevance of CEFTIZOXIME SODIUM

• The most active antimicrobial drugs (inhibiting > 90% of the isolates) for aerobic microorganisms encountered most often (E. coli and Pasteurella sp) included amikacin, ceftizoxime sodium, enrofloxacin, and gentamicin sulfate [1].
• The influence of normal human serum on bactericidal activity of ceftizoxime sodium (CZX) was studied in vitro against Escherichia coli and Staphylococcus aureus [2].
• Toxicity and reproduction studies of ceftizoxime sodium [3].

High impact information on CEFTIZOXIME SODIUM

• The oral bioavailability of new formulations of ceftizoxime sodium was investigated in animals and humans [4].
• Ceftizoxime sodium caused significant extent of lipid peroxidation [5].
• The single-dose pharmacokinetics of ceftizoxime sodium were studied in 52 neonates and infants between 0.1 and 189 days of age [6].
• The in vitro antibacterial activity of ceftizoxime (Cefizox) is influenced by the ambient pH of the medium [7].
• The i.v. LD50 values of ceftizoxime sodium in mice and rats were around 6000 mg/kg, and no deaths occurred in dogs after the largest dose of 3200 mg/kg [3].

Associations of CEFTIZOXIME SODIUM with other chemical compounds

• In different sets of experiment lipid peroxidation induction capacity of two drugs, viz., ceftizoxime sodium, a third generation cephalosporin antibiotic, and acyclovir, an antiviral agent, was studied using goat whole blood as the lipid source [5].

Analytical, diagnostic and therapeutic context of CEFTIZOXIME SODIUM

• In the synthesis of ceftizoxime sodium, eight process related impurities were detected in HPLC analysis [8].

References