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Chemical Compound Review

SureCN2465593     1-[3-(3,4,5- trimethoxyphenyl)prop-2- enoyl]...

Synonyms: SPBio_002727, AC1L9D5T, Prestwick0_000604, Prestwick1_000604
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Disease relevance of C10166


High impact information on C10166

  • Among them, piplartine showed the most potent anti-platelet aggregation activity induced by collagen and showed an IC50 value of 21.5 microM [3].
  • Piperarborenine C, (+)-diayangambin, piplartine, piperolactam B, piperolactam C, aristolactam BIII, goniothalactam, and methyl trans-3,4,5-trimethoxycinnamate possessed anti-platelet aggregation activity in vitro [3].
  • The viability of all human leukemia cell lines were not affected by piplartine after 6h, 9h, and 12h exposure, whereas a steady decline was seen after an exposure time of 24h [4].
  • Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways [4].
  • Piplartine-mediated reduction in cell number was associated with an increasing number of dead cells at a concentration of 10mug/ml [4].

Biological context of C10166

  • Our findings suggest that piplartine can suppress leukemia growth and reduce cell survival, triggering both apoptosis and/or necrosis, depending on the concentration used [4].
  • The antitumor activity of piplartine was related to inhibition of the tumor proliferation rate, as observed by reduction of Ki67 staining, a nuclear antigen associated with G1, S, G2, and M cell cycle phases, in tumors from treated animals [1].

Associations of C10166 with other chemical compounds

  • A rapid, sensitive and reliable reverse-phase HPLC method was used for the quantitative determination of the anti-fungal and insecticide amides, dihydropiplartine (1), piplartine (2), deltaalpha,beta-dihydropiperine (3) and pellitorine (4) in plants in natura, in plantlets in vitro and ex vitro, and in callus of Piper tuberculatum [5].
  • The purpose of the present study was to examine the antiproliferative effects of piplartine on human leukemia cell lines HL-60, K562, Jukart, and Molt-4 using the trypan blue exclusion method, as well as the effect of piplartine on DNA synthesis [4].


  1. In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Bezerra, D.P., Castro, F.O., Alves, A.P., Pessoa, C., Moraes, M.O., Silveira, E.R., Lima, M.A., Elmiro, F.J., Costa-Lotufo, L.V. Braz. J. Med. Biol. Res. (2006) [Pubmed]
  2. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Bezerra, D.P., Pessoa, C., de Moraes, M.O., Silveira, E.R., Lima, M.A., Elmiro, F.J., Costa-Lotufo, L.V. Z. Naturforsch., C, J. Biosci. (2005) [Pubmed]
  3. New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Tsai, I.L., Lee, F.P., Wu, C.C., Duh, C.Y., Ishikawa, T., Chen, J.J., Chen, Y.C., Seki, H., Chen, I.S. Planta Med. (2005) [Pubmed]
  4. Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways. Bezerra, D.P., Milit??o, G.C., de Castro, F.O., Pessoa, C., de Moraes, M.O., Silveira, E.R., Lima, M.A., Elmiro, F.J., Costa-Lotufo, L.V. Toxicology in vitro : an international journal published in association with BIBRA (2007) [Pubmed]
  5. Quantitative determination of anti-fungal and insecticide amides in adult plants, plantlets and callus from Piper tuberculatum by reverse-phase high-performance liquid chromatography. Navickiene, H.M., Bolzani, V.d.a. .S., Kato, M.J., Pereira, A.M., Bertoni, B.W., França, S.C., Furlan, M. Phytochemical analysis : PCA. (2003) [Pubmed]
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