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Chemical Compound Review:

CHEBI:16578 [(2R,3S,4R,5R)-5-(4-amino-2- oxo-pyrimidin...

Synonyms: AC1L9E85, C11435, 263016-94-0, CDM, 4-diphosphocytidyl-2-C-methylerythritol, ...

Lherbet, C. et al., Koppisch, A.T. et al., Hsieh, M.H. et al., Kemp, L.E. et al.

Hsieh, Goodman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cytidine 5'-{3-[(2R,3S)-2,3,4-trihydroxy-3-methylbutyl] dihydrogen diphosphate}

In Agrobacterium tumefaciens the ispD and ispF genes are fused to encode a bifunctional enzyme that catalyzes the first (synthesis of 4-diphosphocytidyl-2-C-methyl d-erythritol) and third (synthesis of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate) steps [1].
The E. coli IspF protein catalyzes a unique cyclization reaction to convert 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate in the nonMVA pathway [2].

High impact information on cytidine 5'-{3-[(2R,3S)-2,3,4-trihydroxy-3-methylbutyl] dihydrogen diphosphate}

2-C-Methyl-D-erythritol 4-phosphate (MEP, 2) and 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDPME, 3) are metabolites in the MEP pathway for biosynthesis of isoprenoid compounds in bacteria, plant chloroplasts, and algae [3].

Analytical, diagnostic and therapeutic context of cytidine 5'-{3-[(2R,3S)-2,3,4-trihydroxy-3-methylbutyl] dihydrogen diphosphate}

Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase [4].

References

Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Lherbet, C., Pojer, F., Richard, S.B., Noel, J.P., Poulter, C.D. Biochemistry (2006) [Pubmed]
Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis. Hsieh, M.H., Goodman, H.M. Planta (2006) [Pubmed]
Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol and 2-C-methyl-D-erythritol-4-phosphate. Koppisch, A.T., Poulter, C.D. J. Org. Chem. (2002) [Pubmed]
Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase. Kemp, L.E., Bond, C.S., Hunter, W.N. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]

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