Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

BQ-518 2-[(3R,6R,9S,12R,15S)-6-(1H- indol-3...

Synonyms: CHEMBL2074702, AC1L9EDN, BQ 518, C11589

Fukami, T. et al., Akhteruzzaman, S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on C11589

Among synthesized cyclic pentapeptides, compound 36 (BQ-518) was the most potent ETA receptor antagonist, with a pA2 of 8.1 against ET-1-induced vasoconstriction in isolated porcine coronary arteries [1].
BQ-485, a linear peptide, BQ-518, a cyclic peptide, and compound A, a cyclic peptide with a cationic moiety, were taken up by hepatocytes in a concentration-dependent manner [2].

References

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. Fukami, T., Nagase, T., Fujita, K., Hayama, T., Niiyama, K., Mase, T., Nakajima, S., Fukuroda, T., Saeki, T., Nishikibe, M. J. Med. Chem. (1995) [Pubmed]
Carrier-mediated hepatic uptake of peptidic endothelin antagonists in rats. Akhteruzzaman, S., Kato, Y., Kouzuki, H., Suzuki, H., Hisaka, A., Stieger, B., Meier, P.J., Sugiyama, Y. J. Pharmacol. Exp. Ther. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share