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Chemical Compound Review

AC1L9JAF     [(2S)-2-amino-3-(1H-indol-3...

Synonyms: DB01831, TYM, TRYPTOPHANYL-5'AMP
 
 
 
 
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High impact information on [(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]oxy-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy]phosphinic acid

  • The dimeric structure (R = 23.7, Rfree = 26.2) is asymmetric, unlike that of the TrpRS tryptophanyl-5'AMP complex (TAM; Doublié S, Bricogne G, Gilmore CJ, Carter CW Jr, 1995, Structure 3:17-31) [1].

References

  1. 2.9 A crystal structure of ligand-free tryptophanyl-tRNA synthetase: domain movements fragment the adenine nucleotide binding site. Ilyin, V.A., Temple, B., Hu, M., Li, G., Yin, Y., Vachette, P., Carter, C.W. Protein Sci. (2000) [Pubmed]
 
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