Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Apogossypol 3-methyl-5-propan-2-yl-2- (1,6,7-trihydroxy...

Synonyms: CNDO-103, CHEMBL551288, SureCN2513478, NSC-736630, AC1L9RXE, ...

Coward, L. et al., Shelley, M.D. et al., Becattini, B. et al.

Shelley, Hartley, Groundwater, Fish, Coward, Gorman, Noker, Kerstner-Wood, Pellecchia, Reed, Jia,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Apogossypol

Our compound, Apogossypol, is capable of binding and inhibiting Bcl-2 and Bcl-X(L) with high affinity and induces apoptosis of tumor cell lines [1].
A simple and selective liquid chromatography/tandem mass spectrometry (LC/MS/MS) method based on internal standard quantitation using apigenin as the internal standard has been developed and validated for the analysis of the gossypol analog apogossypol, a pro-apoptotic compound, in mouse plasma [2].
In contrast, the racemic bis Schiff's base derivative of gossypol 1c and apogossypol 1b showed minimal activity in any cell line up to 50 microM [3].

References

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Becattini, B., Kitada, S., Leone, M., Monosov, E., Chandler, S., Zhai, D., Kipps, T.J., Reed, J.C., Pellecchia, M. Chem. Biol. (2004) [Pubmed]
Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. Coward, L., Gorman, G., Noker, P., Kerstner-Wood, C., Pellecchia, M., Reed, J.C., Jia, L. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
Structure-activity studies on gossypol in tumor cell lines. Shelley, M.D., Hartley, L., Groundwater, P.W., Fish, R.G. Anticancer Drugs (2000) [Pubmed]

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