Disease relevance of Loditac

• Because no toxicity was observed with oxibendazole or RS-95005-000, the negative results obtained with these two compounds could not be considered definitive [1].
• Treatment administered on postinoculation day (PID) 28 included no treatment (control), 0.2 mg of ivermectin/kg of body weight, 10 mg of oxibendazole/kg, or 6.6 mg of pyrantel base (pamoate)/kg [2].
• The anthelmintic efficacy and safety of the oxibendazole component in a combination oxibendazole-niclosamide paste were investigated in dogs and cats and in litters of pups with naturally acquired nematode infections [3].

High impact information on Loditac

• The significant differences in residue bioavailability and extraction efficiency between the fortified control and dosed tissues indicate that little, if any, parent oxibendazole is present in the dosed tissues, even at early withdrawal times [4].
• The calculated grazing area lost to feces was three times greater for ivermectin plots than for oxibendazole or control plots [5].
• Experimental and theoretical studies of albendazole, oxibendazole, and tioxidazole [6].
• A comparison of the anthelmintic effects of oxfendazole and oxibendazole on Trichinella spiralis in mice [7].
• In 3 separate studies, oxibendazole in drench and premix formulation was shown efficacious against larvae and adults of the genera Haemonchus, Ostertagia, Trichostrongylus, Strongyloides, Nematodirus, Cooperia, Bunostomum, Capillaria, Oesophagostomum, and Trichuris [8].

Chemical compound and disease context of Loditac

• Levamisole, mebendazole, and oxibendazole were ineffective in controlling intense natural parasitic infections of sheep at daily oral dose levels equal to or less than 1 mg/kg of body weight and/or a feeding level equal to or less than 10 mg/kg of feed [9].

Associations of Loditac with other chemical compounds

• RESULTS: Moxidectin (0.4 mg/kg) suppressed faecal egg counts for 109 days after treatment in most horses compared to 40 days with ivermectin (0.2 mg/kg), 13 days with morantel (9.4 mg/kg) and less than 13 days with oxibendazole (10 mg/kg) [10].

Analytical, diagnostic and therapeutic context of Loditac

• Critical tests and clinical trials on oxibendazole in horses with special reference to removal of Parascaris equorum [11].
• In 1989, the effects of treating horses with oral ivermectin or oxibendazole compared with untreated controls were quantified in a study with 21 horses under natural grazing conditions after treatment on 7 June [5].
• Plasma disposition, faecal excretion and in vitro metabolism of oxibendazole following oral administration in horses [12].

References