Disease relevance of Basalin

• Cultured human lymphocytes were exposed to three different concentrations (2.5, 5.0 and 10.0 micrograms/ml) of fluchloralin for 24 and 48 h to assess chromosomal aberrations [1].
• Subacute toxicity of Basalin in rats [2].

Psychiatry related information on Basalin

• The maximum carotene content, T.S.S. and organoleptic characteristics were observed with the application of 80 kg. nitrogen/ha and fluchloralin herbicide at 0.90 and 1.20 kg/ha [3].

High impact information on Basalin

• Agarose gel electrophoresis of DNA from herbicide-treated cells and cytochemical staining indicate the induction of apoptosis by fluchloralin [4].
• To understand the mechanism of cell death caused by fluchloralin, its effect on DNA synthesis and its ability to induce apoptosis were investigated [4].
• Treatment of cells for 8-12 hr with fluchloralin resulted in a significant increase in the frequency of metaphase cells with chromosomal damage [4].
• Genotoxicity of the herbicide fluchloralin on human lymphocytes in vitro: chromosomal aberration and micronucleus tests [1].
• Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)] [5].

Biological context of Basalin

• Fluchloralin is cytotoxic and genotoxic and induces apoptosis in mammalian cells [4].

References