Disease relevance of decanoic acid

• Histopathological analysis revealed mild focal lung inflammation more frequently in the EGTA, C10, and C12 groups than in vehicle controls, with greater intensity in the C12 group relative to the other groups [1].
• In vivo toxicity studies demonstrated no effect of EGTA, C10, or C12 on weight gain, lung edema, or bronchoalveolar lavage fluid (BALF) albumin [1].
• Increased levels of interleukin 8 (IL-8) were secreted from EGTA-pretreated cystic fibrosis HAE cells after apical application of Pseudomonas aeruginosa (10(8) CFU/ml), whereas IL-8 secretion from C10- and C12-pretreated cells was not different from controls [1].
• METHODS: Male Wistar rats were treated with vehicle or 1 mg.100 g(-1) body weight (b.w.) of DECA, once a week for 8 wk, intramuscularly [2].
• Escherichia coli colonies hydrolysed the Pro but not the Lau or Dec esters [3].

High impact information on decanoic acid

• C10 had no effect on BALF cell counts or LDH, but increased murine tumor necrosis factor alpha [1].
• Adenoviral gene transfer to murine trachea in vivo was enhanced more efficiently by C10 than by C12 or EGTA [1].
• However, a C. viscosissima mutant, cpr-1, whose seed oils are deficient in caprate relative to wild type, was impaired in extension of C8 to C10 in this assay and Western analysis revealed a specific deficiency in 46 kDa KAS in cpr-1 embryos [4].
• The results showed caprate (C10) to be the most potent vasorelaxant and basilar arteries to be more responsive (EC50 = 63 microM) than umbilical arteries (EC50 = 780 microM) [5].
• The relaxation was independent of the endothelium, and potency was not related to the weak capacity of caprate to inhibit Ca(2+)-induced contractions of K(+)-depolarized basilar arteries [5].

Chemical compound and disease context of decanoic acid

• In conclusion, chronic treatment with DECA, in rats, impairs tonic cardiac autonomic regulation, which may provide a key mechanism for anabolic steroid-induced arrhythmia and sudden cardiac death [6].
• Developmental toxicity evaluation of trimethylolpropane caprylate caprate in Sprague-Dawley rats [7].

Biological context of decanoic acid

• Accordingly, C10 can be considered a safer enhancer than acylcarnitines [8].
• The absence of the caprate and stearate in plasma may be attributed to the high hydrophobicity or favorable tissue distribution of the ester derivatives [9].
• The substrate specificity towards synthetic ester molecules indicates that Lip7p presented a maximum activity centred on caproate (C6) while that of Lip8p is in caprate (C10) [10].
• When mixed with the absorption enhancers in a ratio of 1:5, only Na caprate improved norfloxacin bioavailability significantly [11].
• Supplementing the standard glucose feed with lipids such as caprylate or caprate, and decyl alcohol, affected cell mass minimally but produced higher titers by increasing the specific biosynthesis of A10255 per unit of biomass [12].

Anatomical context of decanoic acid

• DECA treatment induced a significant increase in the absolute and relative thyroid gland weight [2].
• Using brush border membrane (BBM) vesicles prepared from colon, with their protein and lipid component labeled by fluorescent probes, the perturbing actions of caprate and caprylate toward the membrane were examined by fluorescence polarization [13].

Associations of decanoic acid with other chemical compounds

• The composition and positional distribution of lipids in developing and mature transgenic Brassica napus seeds accumulating up to 7 mol% of caprylate (8:0), 29 mol% caprate (10:0) or 63 mol% of laurate (12:0) were examined [14].
• We evaluated the effects on thyroid function of supraphysiologic doses of nandrolone decanoate (DECA), which is one of the most anabolic-androgenic steroids (AAS) used [2].
• Sodium taurocholate, sodium caprylate, and EDTA disodium salts (EDTA-2Na) at 1% enhanced cefmetazole absorption less than caprate, laurate, or mixed micelles, but no such effect was found at 0.25% [15].
• Seven esters of testosterone: acetate, propionate, enanthate, caprate, undecanoate, isobutyrate and isocaproate (some of them are used as drugs) were transformed by microorganisms: Absidia coerulea, Acremonium roseum, Aphanocladium album and Rhodotorula mucilaginosa to obtain some information about their metabolism [16].
• The EDTA and sodium caprate (Na caprate) effects on the oral bioavailability of norfloxacin were tested [11].

Gene context of decanoic acid

• 125I-labelled BSA was retained in the footpad to a significantly greater extent than with a caprate emulsion, but reasons are given for believing that slow release of antigen is not the only mechanism of adjuvant activity [17].

Analytical, diagnostic and therapeutic context of decanoic acid

• The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans [18].
• Site-specific immunosuppression using a new formulation of topical cyclosporine A with polyethylene glycol-8 glyceryl caprylate/caprate [19].

References