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Chemical Compound Review

AG-J-37986     [4-(3-amino-2,6-dichloro- phenyl)-1,2,5...

Synonyms: AC1LAH1Q, CTK6E4007, RD4-2217
 
 
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Disease relevance of RD4-2217

  • Studies on the emergence of drug-resistant mutants revealed that, although much higher concentrations (1-10 microM) were required, RD4-2217 completely suppressed the breakthrough of HIV-1 in the supernatants during long-term culturing of infected cells [1].
  • Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217 [2].
 

High impact information on RD4-2217

 

Analytical, diagnostic and therapeutic context of RD4-2217

  • In this study we examined genotypic and phenotypic characteristics of RD4-2217-resistant mutants that have been obtained by serial passage of HIV-1 in MT-4 cells in the presence of increasing concentrations (0.05, 0.25, 1 and 10 microM) of the compound [2].

References

  1. Thiadiazole derivatives: highly potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replications in vitro. Fujiwara, M., Ijichi, K., Hanasaki, Y., Ide, T., Katsuura, K., Takayama, H., Aimi, N., Shigeta, S., Konno, K., Yokota, T., Baba, M. Microbiol. Immunol. (1997) [Pubmed]
  2. Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217. Fujiwara, M., Kodama, E.N., Okamoto, M., Tokuhisa, K., Ide, T., Hanasaki, Y., Katsuura, K., Takayama, H., Aimi, N., Mitsuya, H., Shigeta, S., Konno, K., Yokota, T., Baba, M. Antivir. Chem. Chemother. (1999) [Pubmed]
 
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