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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

L-ddTTP     [hydroxy-[hydroxy-[[(2R,5S)- 5-(5-methyl-2...

Synonyms: L-ddT-TP, AC1LAN16, 2',3'-Dideoxythymidine-5'- triphosphate
 
 
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Disease relevance of L-ddTTP

  • beta-L-3'-Deoxythymidine 5'-triphosphate (L-ddTTP) and beta-L-3'-deoxy-2',3'-didehydrothymidine 5'-triphosphate (L-d4TTP) were substrates for human immunodeficiency virus reverse transcriptase, Escherichia coli DNA polymerase I (Klenow), and Sequenase (modified T7 DNA polymerase) [1].
 

High impact information on L-ddTTP

  • The Km value of reverse transcriptase for L-ddTTP was 50-fold larger than that for D-ddTTP because the Kd for L-ddTTP was 5-fold larger than that for D-ddTTP, and the first-order rate constant for incorporation of L-ddTMP into the template-primer was 10% that of the D-enantiomer [1].

References

  1. Beta-L-thymidine 5'-triphosphate analogs as DNA polymerase substrates. Van Draanen, N.A., Tucker, S.C., Boyd, F.L., Trotter, B.W., Reardon, J.E. J. Biol. Chem. (1992) [Pubmed]
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