Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Synguanol 2-amino-9-[[2-(hydroxymethyl) cyclopropylid...

Synonyms: AC1LAQUF, AG-J-02063, SureCN5934207, SureCN7488482, CTK4E3149, ...

Baldanti, F. et al.

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High impact information on Synguanol

These results together with those showing resistance of a UL97 knock-out HCMV mutant to GCV as well as synadenol and synguanol suggest the involvement of UL97 phosphotransferase in synadenol and synguanol anabolism but with a substrate specificity different from that of GCV [1].

References

Z-isomers of 2-hydroxymethylcyclopropylidenemethyl adenine (synadenol) and guanine (synguanol) are active against ganciclovir- and foscarnet-resistant human cytomegalovirus UL97 mutants. Baldanti, F., Sarasini, A., Drach, J.C., Zemlicka, J., Gerna, G. Antiviral Res. (2002) [Pubmed]

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