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Chemical Compound Review:

AC1LA62F [5-(2-amino-6-oxo-3H-purin-9- yl)-3-[[5-(4...

Synonyms: 5'-GC-3'

Zhao, C. et al., O'Connor, P.M. et al., Kanony, C. et al., Heininger, K. et al.

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High impact information on AIDS-097596

The proposal is supported by high-performance liquid chromatography-matrix-assisted laser desorption-ionization mass spectrometry experiments that also reveal other sequence-selective frank scissions of lower intensity at 5'-GC-3' or other 5'-CG-3' sites [1].
In order to enlarge the understanding of its structure and reactivity, three-dimensional structures of HO(2)-Co(III)bleomycin bound to two DNA oligomers, d(GAGCTC)(2) (I) and d(GGAAGCTTCC)(2) (II), that have 5'-GC-3' binding sites, have been determined by nuclear magnetic resonance (NMR) methods [2].
UM, however, was somewhat less efficacious in ISC production than was 6-methyl-UM, which lacked selectivity for alkylation at 5'-GC-3'. QM was the only compound that produced detectable SSB, and the SSB were so numerous that ISC could not be quantitated.(ABSTRACT TRUNCATED AT 250 WORDS)[3]

Analytical, diagnostic and therapeutic context of AIDS-097596

By sequence analyses it is shown that the reduction in specificity of Bsu corresponds to cleavage predominantly at 5'-GC-3' 3'-CG-5' sequences [4].

References

Photosensitization of DNA damage by a new cationic pyropheophorbide derivative: sequence-specific formation of a frank scission. Kanony, C., Fabiano-Tixier, A.S., Ravanat, J.L., Vicendo, P., Paillous, N. Photochem. Photobiol. (2003) [Pubmed]
Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins. Zhao, C., Xia, C., Mao, Q., Försterling, H., DeRose, E., Antholine, W.E., Subczynski, W.K., Petering, D.H. J. Inorg. Biochem. (2002) [Pubmed]
Comparative pharmacokinetics of DNA lesion formation and removal following treatment of L1210 cells with nitrogen mustards. O'Connor, P.M., Kohn, K.W. Cancer Commun. (1990) [Pubmed]
Specificity of cleavage by restriction nuclease from Bacillus subtilis. Heininger, K., Hörz, W., Zachau, H.G. Gene (1977) [Pubmed]

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