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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AC1LA62L     [5-(2-amino-6-oxo-3H-purin-9- yl)-3...

Synonyms: 5'-GT-3'
 
 
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High impact information on AIDS-097598

  • Tandem repeats of sequences of 5'-AC-3' and 5'-ACACATGC-3' in the 5' flanking region, of 5'-GAAA-3' in the first intron, and of 5'-GT-3' in the third intron of the gene were observed [1].
  • A new set of end-cap heterocycle dimers, oxazole-hydroxybenzimidazole (No-Hz) and chlorothiophene-hydroxybenzimidazole (Ct-Hz), paired with Py-Py are shown to bind contiguous base pairs of DNA in the minor groove, specifically 5'-GT-3' and 5'-TT-3', with high affinity and selectivity [2].

References

  1. Structure and expression of the rat transthyretin (prealbumin) gene. Fung, W.P., Thomas, T., Dickson, P.W., Aldred, A.R., Milland, J., Dziadek, M., Power, B., Hudson, P., Schreiber, G. J. Biol. Chem. (1988) [Pubmed]
  2. Programmable oligomers for minor groove DNA recognition. Doss, R.M., Marques, M.A., Foister, S., Chenoweth, D.M., Dervan, P.B. J. Am. Chem. Soc. (2006) [Pubmed]
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