Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-K-44487 (3S,10R,13S)-3-[[4-(2- hydroxyethoxy)phenyl...

Synonyms: CHEBI:66740, AC1LAJ0V, CTK6C9874, PF1163A, (-)-PF 1163A

Nose, H. et al., Nose, H. et al.

Nose, Fushimi, Seki, Sasaki, Watabe, Hoshiko,

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High impact information on PF1163A

The ERG25 strain overexpressing the ERG25 gene was resistant to PF1163A [1].
PF1163A and B are a pair of antifungal agents isolated from a fermentation broth of Penicillium sp. PF1163A inhibited ergosterol synthesis in Saccharomyces cerevisiae, resulting in an accumulation of 4,4-dimethylzymosterol and a decrease of ergosterol [1].
Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies [2].

References

PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. Nose, H., Fushimi, H., Seki, A., Sasaki, T., Watabe, H., Hoshiko, S. J. Antibiot. (2002) [Pubmed]
PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. Nose, H., Seki, A., Yaguchi, T., Hosoya, A., Sasaki, T., Hoshiko, S., Shomura, T. J. Antibiot. (2000) [Pubmed]

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