Disease relevance of potassium peroxide

• Comparison of the inactivation of Bacillus subtilis transforming DNA by the potassium superoxide and xanthine-xanthine oxidase systems for generating superoxide [1].
• Oxygen centered radicals derived from potassium superoxide (KO2) in solution were found to be toxic to P815 mastocytoma target cells [2].
• Chinese hamster ovary cells and human P3 teratocarcinoma cells were exposed to superoxide anion (O2-) generated by the addition of potassium superoxide (KO2) [3].

High impact information on potassium peroxide

• Only O-2 produced by granulocytes is sufficient for iron mobilization, because solid potassium superoxide is also able to release iron from ferritin [4].
• A similar CL response is seen when retinoic acid is incubated with potassium superoxide in a cell-free system [5].
• They suppressed the inactivation of several enzymes including citrate synthase and 6-phosphogluconate dehydrogenase by heat, potassium superoxide, hydrogen peroxide and freeze-thawing, but not the inactivation of glyceraldehyde-3-phosphate dehydrogenase by hydrogen peroxide [6].
• Similarly, the prevention of deactivation by potassium superoxide was also demonstrated for the integral membrane protein succinate dehydrogenase by intact cell assay [7].
• Chinese hamster ovary cells in vitro were exposed to superoxide anion (O2-) generated by the addition of potassium superoxide (KO2) to the cell culture media [8].

Biological context of potassium peroxide

• The SOD profiles of D. radiophilus at the exponential phase received oxidative stress by the potassium superoxide treatment or UV irradiation also revealed the occurrence of a single SOD [9].

Anatomical context of potassium peroxide

• Potassium superoxide (KO.2), applied as a source of superoxide radical directly in vitro to white matter from young adult human brain, caused the lipid phase of the myelin to change from a crystalline (ordered) state to a liquid crystalline (disordered) state [10].
• Potassium superoxide induction of rabbit corneal endothelial cell damage [11].
• This signal was also observed in freshly prepared ghosts treated with potassium superoxide and in old erythrocyte ghosts [12].
• To investigate possibility of a superoxide radical bomb, the role of an oxyradical on the spermatozoon was studied in vitro using potassium superoxide, a potent superoxide radical producer [13].

Associations of potassium peroxide with other chemical compounds

• Endothelial intracellular glutathione levels and redox state were unaffected by perfusion with a solution to which 0.3 mM potassium superoxide had been added [11].
• The reaction of OPC-14117 and superoxide anion, generated in potassium superoxide, was examined by electron spin resonance technique at both liquid nitrogen (77 K) and room (22 degrees C) temperatures [14].
• Candida albicans mutants with mutations in mitogen-activated protein (MAP) kinase HOG1 displayed an increased sensitivity to agents producing reactive oxygen species, such as oxidants (menadione, hydrogen peroxide, or potassium superoxide), and UV light [15].
• The possible role of oxygen radicals formed secondary to semi-quinone formation in the inactivation of DNA by the semi-quinone free radical was investigated using the hydroxyl radical scavengers t-butanol and DMSO, the spin trap DMPO, the enzymes catalase and superoxide dismutase, the iron chelator EDTA and potassium superoxide [16].

References