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Chemical Compound Review:

CINNAMAMIDE (E)-3-phenylprop-2-enamide

Synonyms: AC1NRUZZ, PubChem11078, Cinnamic amide, SureCN649508, SureCN649509, ...

Schüder, I. et al., Malml??f, K. et al., Jiang, X.F. et al., Buzzetti, F. et al., Jiang, X. et al., et al.

Schüder, Port, Bennison,

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Disease relevance of NSC 32953

When administered i.p., cinnamamide not only inhibited the growth of transplanted tumors but also reduced the number of lung metastases in mice bearing Lewis lung carcinoma [1].

Psychiatry related information on NSC 32953

The most effective product, cinnamamide, reduced snail locomotor activity by 94% and track length by 96% [2].

High impact information on NSC 32953

In situ X-ray observation of pedal-like conformational change and dimerization of trans-cinnamamide in cocrystals with phthalic acid [3].
The antitumor activity of cinnamamide (CNM), an agent acting on matrix metalloproteinase (MMP), was investigated in the present study [4].
OBJECTIVE: The purpose of the present study was to examine the metabolic effects of a specific histamine H(3) receptor antagonist, the cinnamic amide NNC 0038-0000-1202 (NNC 38-1202) [5].
Low-light video-recording in combination with automated tracking and event recording was used to identify the repellent and irritant effects of (1) cinnamamide, (2) copper ammonium carbonate, (3) a mulch, (4) a horticultural ground-cover matting impregnated with a copper formulation and (5) urea/formaldehyde [2].
Here we describe synthesis and biochemical testing of a novel series of non-peptide PTK inhibitors which have as characteristic active pharmacophore the cinnamamide moiety [6].

References

Antitumor components from an actinomycete strain 6011W. Jiang, X.F., Shang, B.Y., Jin, L.F., Hu, J.L., Zhen, Y.S. Journal of Asian natural products research. (1999) [Pubmed]
The behavioural response of slugs and snails to novel molluscicides, irritants and repellents. Schüder, I., Port, G., Bennison, J. Pest Manag. Sci. (2004) [Pubmed]
In situ X-ray observation of pedal-like conformational change and dimerization of trans-cinnamamide in cocrystals with phthalic acid. Ohba, S., Hosomi, H., Ito, Y. J. Am. Chem. Soc. (2001) [Pubmed]
Cinnamamide, an antitumor agent with low cytotoxicity acting on matrix metalloproteinase. Jiang, X., Zhen, Y. Anticancer Drugs (2000) [Pubmed]
Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. Malml??f, K., Golozoubova, V., Peschke, B., Wulff, B.S., Refsgaard, H.H., Johansen, P.B., Cremers, T., Rimvall, K. Obesity (Silver Spring, Md.) (2006) [Pubmed]
Cinnamamide analogs as inhibitors of protein tyrosine kinases. Buzzetti, F., Brasca, M.G., Crugnola, A., Fustinoni, S., Longo, A., Penco, S., Dalla Zonca, P., Comoglio, P.M. Farmaco (1993) [Pubmed]

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