Disease relevance of C10040

• Therefore, eupatilin might be therapeutically efficacious in a variety of human liver diseases associated with cholestasis [1].
• In the present study, we examined the ability of eupatilin to induce apoptosis in human gastric cancer (AGS) cells [2].

High impact information on C10040

• In addition, eupatilin treatment led to elevated expression of p53 and p27Kip1 that act as Cdk inhibitors [3].
• Eupatilin inhibited the activation of ERK1/2 as well as expression of Raf-1 and Ras in MCF10A-ras cells [3].
• Thus, the inhibitory effect of eupatilin on cyclin D1 expression appears to be mediated by targeting the Raf/MEK/ERK signaling cascades [3].
• Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), one of the pharmacologically active ingredients derived from A. asiatica, was shown to induce apoptosis in human promyelocytic leukemia (HL-60) cells [Mutat Res 496 (2001) 191] [3].
• To explore whether the anti-proliferative effects of eupatilin could be mediated through modulation of the cell cycle in MCF10A-ras, DNA contents were analyzed by the flow cytometry [3].

Biological context of C10040

• Eupatilin did not change activation of Akt, an important component of cell-survival pathways [3].
• Downregulation of cyclin D1 expression by eupatilin was accompanied by a reduced expression of c-Jun and the DNA binding activity of the transcription factor AP-l. The expression of p21waf1/Cip1 was also decreased by eupatilin treatment in both protein and the mRNA levels [4].
• Eupatilin induced the apoptosis of AGS cells as revealed by a decrease in the ratio of pro-apoptotic Bax and anti-apoptotic Bcl-2, as well as the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP).The pro-apoptotic effects of eupatilin were further verified by its perturbation of the mitochondrial transmembrane potential (DeltaPsim) [2].

Anatomical context of C10040

• Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells [3].
• Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells [5].

Associations of C10040 with other chemical compounds

• The aerial parts of ARTEMISIA MONGOLICA afforded the eudesmane derivative ludovicin B, two coumarins, umbelliferone and esculetin, two methoxylated flavones, eupatilin and pectolinarigenin, as well as a new eudesmane sesquiterpene, 6alpha,8alpha -dihydroxyisocostic acid methyl ester [6].

Gene context of C10040

• We concluded that the inhibitory effect of eupatilin on p21waf1/Cip1 expression is likely to be associated with the downregulation of cyclin D1 expression and AP-1 activation, which play an important role in the cell cycle arrest of ras-transformed breast epithelial cells [4].
• Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells [7].

Analytical, diagnostic and therapeutic context of C10040

• Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry [8].

References