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Chemical Compound Review

Eupatilin     2-(3,4-dimethoxyphenyl)-5,7- dihydroxy-6...

Synonyms: Euptailin, AC1NRVK5, CHEMBL312750, CHEBI:4932, SureCN1033509, ...
 
 
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Disease relevance of C10040

 

High impact information on C10040

 

Biological context of C10040

  • Eupatilin did not change activation of Akt, an important component of cell-survival pathways [3].
  • Downregulation of cyclin D1 expression by eupatilin was accompanied by a reduced expression of c-Jun and the DNA binding activity of the transcription factor AP-l. The expression of p21waf1/Cip1 was also decreased by eupatilin treatment in both protein and the mRNA levels [4].
  • Eupatilin induced the apoptosis of AGS cells as revealed by a decrease in the ratio of pro-apoptotic Bax and anti-apoptotic Bcl-2, as well as the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP).The pro-apoptotic effects of eupatilin were further verified by its perturbation of the mitochondrial transmembrane potential (DeltaPsim) [2].
 

Anatomical context of C10040

 

Associations of C10040 with other chemical compounds

 

Gene context of C10040

 

Analytical, diagnostic and therapeutic context of C10040

References

  1. Eupatilin attenuates bile acid-induced hepatocyte apoptosis. Park, S.C., Yoon, J.H., Kim, W., Gwak, G.Y., Kim, K.M., Lee, S.H., Lee, S.M., Lee, H.S. J. Gastroenterol. (2006) [Pubmed]
  2. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. Kim, M.J., Kim, D.H., Na, H.K., Oh, T.Y., Shin, C.Y., Surh Ph D Professor, Y.J. J. Environ. Pathol. Toxicol. Oncol. (2005) [Pubmed]
  3. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. Kim, D.H., Na, H.K., Oh, T.Y., Kim, W.B., Surh, Y.J. Biochem. Pharmacol. (2004) [Pubmed]
  4. Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells. Kim, D.H., Na, H.K., Oh, T.Y., Shin, C.Y., Surh, Y.J. J. Environ. Pathol. Toxicol. Oncol. (2005) [Pubmed]
  5. Eupatilin has an antiapoptotic action on hepatocytes, in contrast to apoptotic actions on other cells. Mine, T. J. Gastroenterol. (2006) [Pubmed]
  6. New Eudesmane Sesquiterpene and Other Constituents from Artemisia mongolica. Hu, J., Zhu, Q., Bai, S., Jia, Z. Planta Med. (1996) [Pubmed]
  7. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Seo, H.J., Surh, Y.J. Mutat. Res. (2001) [Pubmed]
  8. Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry. Ji, H.Y., Lee, H.W., Shim, H.J., Kim, S.H., Kim, W.B., Lee, H.S. Biomed. Chromatogr. (2004) [Pubmed]
 
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