High impact information on Chryseriol

• Selective bronchodilatory effect of Rooibos tea (Aspalathus linearis) and its flavonoid, chrysoeriol [1].
• Using the in silico model for flavone, kaempferol and chrysoeriol, the apparent Ki value for inhibition of the active transport to the apical side was estimated to be below 53 muM and for morin, robinetin and taxifolin between 164 and 268 muM [2].
• Phytochemical analysis of the ground aerial parts of Artemisia arborescens resulted in the isolation from the ethanolic extract of the known compounds: artemitin, arborescin, sesamin, (+)-lirioresinol beta-dimethyl ether, chrysoeriol, apigenin, beta-sitosteryl glucoside, dihydroridentin, and chrysoeriol 4-glucoside [3].
• Additionally, the presence of two luteolin, three apigenin, one chrysoeriol, and six tricin glycosides, previously identified in alfalfa (Medicago sativa), was confirmed in M. truncatula [4].
• This presumed inhibitory effect on AP-1 activation by chrysoeriol may be associated with its potent NO blocking and anti-inflammatory effects [5].

Biological context of Chryseriol

• O-glycosylation of chrysoeriol decreases its ability to inhibit lipid peroxidation and reaction with peroxyl radicals [6].

Anatomical context of Chryseriol

• In the present study, we isolated chrysoeriol from the leaves of Digitalis purpurea (foxglove), and studied its effect on the induction of the inducible nitric oxide synthase (iNOS) gene, and the mechanism of this induction in Raw264.7 macrophages [5].

Associations of Chryseriol with other chemical compounds

• Alfalfa (Medicago sativa L.) flavonoids. 2. Tricin and chrysoeriol glycosides from aerial parts [7].
• Bioactivity-guided fractionation of an ethanol extract of the aerial parts of Dioscorea opposita afforded a new compound, 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (1), and four known compounds, chrysoeriol 4'-O-beta-D-glucopyranoside (2), chrysoeriol 7-O-beta-D-glucopyranoside (3), alternanthin (4), and daucosterol [8].
• Chrysoeriol pretreatment potently inhibited the release of NO in the cells treated with lipopolysaccharide (LPS), and Western blot and RT-PCR analyses revealed that chrysoeriol inhibited the LPS-induced inductions of iNOS gene [5].

Gene context of Chryseriol

• Based on all these studies it is concluded that chrysoeriol exhibits potent antioxidant activity [6].

References