Disease relevance of Cryptoxanthine

• Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study [1].
• IUGR was associated with increased cryptoxanthin levels in cord blood [2].

Psychiatry related information on Cryptoxanthine

• METHODS: The association of lifestyle factors including alcohol use, physical activity and dietary habits with serum levels of carotenoids (lycopene, lutein, cryptoxanthin and beta-carotene), retinol and alpha-tocopherol were studied in 194 healthy men aged 24-60 years who smoked > 15 cigarettes/day [3].

High impact information on Cryptoxanthine

• CONCLUSIONS: Among nonsmokers, exposure to passive smoking tended to be associated with lower serum concentrations of the carotenoids most strongly associated with active smoking (total carotenoids, alpha-carotene, ss-carotene, and cryptoxanthin) [4].
• A case-control study examined the association between cervical intra-epithelial neoplasia (CIN) and serum and dietary alpha-carotene, beta-carotene, cryptoxanthin, lutein, and lycopene [5].
• RESULTS: General linear regression with adjustments for dietary intake showed that smokers possess lower serum concentrations of beta- and alpha-carotene, cryptoxanthin, lutein, and zeaxanthin (P </= 0.01) and a significantly higher serum gamma-tocopherol (P = 0.03) [6].
• When the concentrations of serum carotenoids were adjusted for serum triglycerides or LDL, correlations between serum carotenoid concentrations and breast adipose tissue carotenoid levels markedly increased, including that of cryptoxanthin (P <0. 001) [7].
• The effect of regucalcin in stimulating osteoclast-like cell formation was significantly inhibited in the presence of calcitonin (CT; 10(-9)M), 17beta-estradiol (10(-9)M), beta-cryptoxanthin (CX; 10(-6)M), or zinc sulfate (10(-4)M), which is an anti-bone resorbing factor [8].

Biological context of Cryptoxanthine

• Knowledge of acylated cryptoxanthin isomers may be important in the evaluation of the bioavailability of individual esters in future human digestion studies [9].

Associations of Cryptoxanthine with other chemical compounds

• Plasma concentrations of alpha- and gamma-tocopherol, alpha- and beta-carotene, lycopene, cryptoxanthin, retinol, ascorbate and malondialdehyde were determined by HPLC; dietary intake and food pattern had been assessed by four 24-h dietary intake recalls and one food frequency questionnaire [10].
• The contents of the segments were removed and analyzed for content of zeacarotene, cryptoxanthin (monohydroxycarotenoid), and lutein (dihydroxycarotenoid) by high pressure liquid chromatography [11].

Gene context of Cryptoxanthine

• Of all the antioxidant nutrients studied, the ORs were higher with higher intakes of cryptoxanthin (OR = 1.44, 95% CI = 1.09-1.89 for 4th quartile) [12].
• To identify esters of structural cryptoxanthin isomers in native orange juice extracts, four saturated acyl esters were synthesized [9].

References