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Chemical Compound Review:

H4530_ALDRICH 7-hydroxy-2-phenyl-chromen-4- one

Synonyms: CHEMBL276915, SureCN312148, CPD-8141, ACMC-1BA9R, AG-L-64363, ...

Vajragupta, O. et al., Zhai, S. et al., Ibrahim, A.R. et al.

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Disease relevance of NSC94258

Manganese complex 3 from 7-hydroxyflavone was the promising candidate for radical implicated neurodegenerative diseases [1].

Psychiatry related information on NSC94258

Only manganese complexes of kojic acid (1) and 7-hydroxyflavone (3) exhibited the significant suppressions on MAP-induced hypermotility and did not significantly decrease the locomotor activity in normal condition [1].

High impact information on NSC94258

For CYP1A1, 7-hydroxyflavone exhibited a competitive mode of inhibition, with a Ki value of 0.015 microM and 6-fold selectivity for CYP1A1 over CYP1A2 [2].
7-Hydroxyflavone (11) was the most effective competitive inhibitor (IC50 = 0.5 microM) with an apparent Ki value of 0.25 microM [3].

References

Manganese-based complexes of radical scavengers as neuroprotective agents. Vajragupta, O., Boonchoong, P., Sumanont, Y., Watanabe, H., Wongkrajang, Y., Kammasud, N. Bioorg. Med. Chem. (2003) [Pubmed]
Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids. Zhai, S., Dai, R., Friedman, F.K., Vestal, R.E. Drug Metab. Dispos. (1998) [Pubmed]
Aromatase inhibition by flavonoids. Ibrahim, A.R., Abul-Hajj, Y.J. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]

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