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Chemical Compound Review:

SITS 5-acetamido-2-[(E)-2-(4- isothiocyanato-2...

Synonyms: IADS, AC1NQZQ7, CHEMBL1162149, NSC-328387, NSC-649691, ...

Labotka, R.J. et al., Saldeña, T.A. et al., Dowrick, P. et al., Liu, L. et al., Trachtman, H. et al., et al.

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High impact information on 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid

Addition of oubain and the anionic binding site inhibitors, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid and 4,4'diisothio-cyanatostilbene-2,2'-disulfonic acid, also decreased cerebral taurine uptake under normoglycemic and hyperglycemic conditions (P less than 0.01) [1].
Suspensions of intact, Cl(-)-loaded erythrocytes (intracellular pH, 7.2) were incubated at 37 degrees C in isotonic buffers (pH 4-8) containing 60 mM phosphate analog for specified time intervals, whereupon influx was halted by the addition of 1 mM 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS), an inhibitor of anion exchange [2].
The drugs amiloride and SITS (4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid) also completely inhibited ruffle formation, suggesting that ion transport was an early consequence of HGF/SF binding and that these transport effects had a major role in the cytoskeletal changes leading to circular ruffle formation [3].
ICl(Ca) was partially suppressed by 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS) when it was locally applied to the axon terminal but not to the cell body region, suggesting that Ca(2+)-dependent Cl- channels were localized to the axon terminal [4].
The effects on short-circuit current of replacement of normal Ringer by a low (2.5 mmol/L) Cl solution and of blockers of basolateral Na, K, 2 Cl symport (bumetanide), apical Cl channels (diphenylamine-2-carboxylate, DPC), and anion exchange (4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid, SITS) alone and combined were assessed [5].

Associations of 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid with other chemical compounds

This study investigates the effect of stilbene disulfonic acids, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS), 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid (SITS), and 4-acetamido-4'-maleimidylstilbene-2,2'-disulfonic acid (AMDS), on synexin-mediated liposome aggregation and fusion [6].

References

Cerebral taurine transport is increased during streptozocin-induced diabetes in rats. Trachtman, H., Futterweit, S., Sturman, J.A. Diabetes (1992) [Pubmed]
The pH dependence of red cell membrane transport of titratable anions studied by NMR spectroscopy. Labotka, R.J., Omachi, A. J. Biol. Chem. (1988) [Pubmed]
Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells. Dowrick, P., Kenworthy, P., McCann, B., Warn, R. Eur. J. Cell Biol. (1993) [Pubmed]
Ca(2+)-dependent Cl- current at the presynaptic terminals of goldfish retinal bipolar cells. Okada, T., Horiguchi, H., Tachibana, M. Neurosci. Res. (1995) [Pubmed]
Pharmacological suppression of rat distal colon chloride secretion requires two blockers. Saldeña, T.A., Sasso, A.J., Cincunegui, L.M., Carra, G.E., Codina, M.V., Saraví, F.D. Acta gastroenterologica Latinoamericana. (2003) [Pubmed]
Stilbene disulfonic acids inhibit synexin-mediated membrane aggregation and fusion. Liu, L., Chander, A. Biochim. Biophys. Acta (1995) [Pubmed]

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