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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

SQ-18506     3-[(E)-2-(5-nitro-2- furyl)ethenyl]-1,2,4...

Synonyms: CCRIS 5440, SureCN7854598, LS-7188, SQ18506, S-18506, ...
 
 
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High impact information on SQ-18506

  • Coadministration of the anticarcinogen BHA with SQ18506 also blocked the chemotherapeutic effects of this agent on female CD-1 mice infected with Schistosoma mansoni [1].
  • Dose-dependent increases in tumors of the forestomach and lymphatic tissues were observed in all groups receiving SQ18506 including mice infected with Schistosoma mansoni [2].
  • The antischistosomal and antitrypanosomal drug trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole [(SQ18506) CAS: 28754-68-9; (E)-amino-3-(2-(5-nitro-2-furyl)-vinyl)-1,2,4-oxadiazole] was carcinogenic for both male and female CD-1 mice when it was administered either in the diet or by gastric intubation [2].
  • Autoradiographic and tissue distribution studies on a nitrovinylfuran derivative (SQ 18506 14C) in S. mansoni infected mice [3].
  • Autoradiographic and tissue distribution studies of SQ 18506 14C were carried out on 13 Swiss albino mice [3].

References

  1. Effects of multiple putative anticarcinogens on the carcinogenicity of trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole. Dunsford, H.A., Dolan, P.M., Seed, J.L., Bueding, E. J. Natl. Cancer Inst. (1984) [Pubmed]
  2. Carcinogenicity of the antischistosomal nitrofuran trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole. Dunsford, H.A., Keysser, C.H., Dolan, P.M., Seed, J.L., Bueding, E. J. Natl. Cancer Inst. (1984) [Pubmed]
  3. Autoradiographic and tissue distribution studies on a nitrovinylfuran derivative (SQ 18506 14C) in S. mansoni infected mice. El-Hawey, A.M., Lan, S.J., Schreiber, E.C. Egyptian journal of bilharziasis. (1976) [Pubmed]
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