Disease relevance of phenoxybenzamine

• Oral therapy with phenoxybenzamine hydrochloride, used in 7 of the 8 patients, reduced the post-void residual urine and produced improvement in hydronephrosis when present [1].
• Treatment of male rats with phenoxybenzamine hydrochloride (PBZ), 70 micrograms/100 g body weight for 5 weeks, caused infertility of the rats [2].
• Contact dermatitis caused by phenoxybenzamine hydrochloride [3].
• Allergic contact dermatitis from phenoxybenzamine hydrochloride: cross-sensitivity to some related haloalkylamine compounds [4].
• The purpose of the present set of experiments was to evaluate the extent to which adrenergic mechanisms contribute to early alterations in regional perfusion during Gram-negative bacteremia, using the mixed alpha adrenergic receptor antagonist phenoxybenzamine hydrochloride [5].

High impact information on phenoxybenzamine

• Prolonged alpha-adrenoceptor blockade with phenoxybenzamine hydrochloride improved the patient's exercise tolerance and postexercise electrocardiographic abnormalities when compared to therapy in matched controls given placebo [6].
• The most significant finding was that 70% of transplanted kidneys came from donors who had recieved pretreatment with either phenoxybenzamine hydrochloride, methylprednisolone sodium succinate, or phentolaminemesylate [7].
• Effects of phenoxybenzamine hydrochloride on canine lower urinary tract: clinical implications [8].
• Phenoxybenzamine hydrochloride, an alpha-adrenergic blocking drug, was chosen because of its potential to attenuate the arterial hypertension previously reported (Ilkiw et al 1988) [9].
• alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis [10].

Chemical compound and disease context of phenoxybenzamine

• A patient found to have a pheochromocytoma in the 16th wk of pregnancy was successfully managed by medical treatment with phenoxybenzamine hydrochloride and propranolol [11].
• Presurgical management with phenoxybenzamine hydrochloride and metyrosine was associated with an absence of expected postoperative hypotension, and resection of a benign ganglioneuroma resulted in prompt relief of all symptoms and return to normal of VIP and NE levels [12].

Anatomical context of phenoxybenzamine

• These animals were studied in intact condition, after administration of phenoxybenzamine hydrochloride, 2 mg/kg, or after bilateral denervation of their carotid bodies [13].

Analytical, diagnostic and therapeutic context of phenoxybenzamine

• We compared a group of 58 patients who received phenoxybenzamine hydrochloride with a control group of 44 patients [14].
• The ulcerations healed after administration of reserpine intraarterially followed by oral administration of phenoxybenzamine hydrochloride [15].
• Phenoxybenzamine hydrochloride, an alpha-receptor blocker, has been our traditional premedication [16].

References