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Chemical Compound Review

AC1NRBUT     (6S)-5-(1-carboxyethenoxy)-6- hydroxy...

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Disease relevance of Isochorismic acid


High impact information on Isochorismic acid


Chemical compound and disease context of Isochorismic acid


Biological context of Isochorismic acid


Associations of Isochorismic acid with other chemical compounds


Gene context of Isochorismic acid

  • The metabolic shift from one diene to the other is caused by a change in activity of isochorismate hydroxymutase and/or isochorismatase which in turn results from growth under iron deficiency or overexpression of genes (entC and/or entB) involved in chrismate metabolism [19].
  • ISR was blocked in Arabidopsis mutants npr1-1, eds5/sid1, and sid2, indicating that components of the pathway from isochorismate and a functional NPR1 play a crucial role in the K165-mediated ISR [20].

Analytical, diagnostic and therapeutic context of Isochorismic acid


  1. The in vitro conversion of chorismate to isochorismate catalyzed by the Escherichia coli entC gene product. Evidence that EntA does not contribute to isochorismate synthase activity. Tummuru, M.K., Brickman, T.J., McIntosh, M.A. J. Biol. Chem. (1989) [Pubmed]
  2. Two Crystal Structures of the Isochorismate Pyruvate Lyase from Pseudomonas aeruginosa. Zaitseva, J., Lu, J., Olechoski, K.L., Lamb, A.L. J. Biol. Chem. (2006) [Pubmed]
  3. Manipulation of salicylate content in Arabidopsis thaliana by the expression of an engineered bacterial salicylate synthase. Mauch, F., Mauch-Mani, B., Gaille, C., Kull, B., Haas, D., Reimmann, C. Plant J. (2001) [Pubmed]
  4. Duplicate isochorismate synthase genes of Bacillus subtilis: regulation and involvement in the biosyntheses of menaquinone and 2,3-dihydroxybenzoate. Rowland, B.M., Taber, H.W. J. Bacteriol. (1996) [Pubmed]
  5. Structural organization of a Bacillus subtilis operon encoding menaquinone biosynthetic enzymes. Rowland, B., Hill, K., Miller, P., Driscoll, J., Taber, H. Gene (1995) [Pubmed]
  6. Recent breakthroughs in the study of salicylic acid biosynthesis. Métraux, J.P. Trends Plant Sci. (2002) [Pubmed]
  7. Mechanistic insights into the isochorismate pyruvate lyase activity of the catalytically promiscuous PchB from combinatorial mutagenesis and selection. Künzler, D.E., Sasso, S., Gamper, M., Hilvert, D., Kast, P. J. Biol. Chem. (2005) [Pubmed]
  8. Salicylate biosynthesis in Pseudomonas aeruginosa. Purification and characterization of PchB, a novel bifunctional enzyme displaying isochorismate pyruvate-lyase and chorismate mutase activities. Gaille, C., Kast, P., Haas, D. J. Biol. Chem. (2002) [Pubmed]
  9. Isochorismate synthase (PchA), the first and rate-limiting enzyme in salicylate biosynthesis of Pseudomonas aeruginosa. Gaille, C., Reimmann, C., Haas, D. J. Biol. Chem. (2003) [Pubmed]
  10. Cloning, mutagenesis, and nucleotide sequence of a siderophore biosynthetic gene (amoA) from Aeromonas hydrophila. Barghouthi, S., Payne, S.M., Arceneaux, J.E., Byers, B.R. J. Bacteriol. (1991) [Pubmed]
  11. Role of the entC gene in enterobactin and menaquinone biosynthesis in Escherichia coli. Kaiser, A., Leistner, E. Arch. Biochem. Biophys. (1990) [Pubmed]
  12. Biosynthesis of o-succinylbenzoic acid. II: Properties of o-succinylbenzoic acid synthase, an enzyme involved in vitamin K2 biosynthesis. Weische, A., Garvert, W., Leistner, E. Arch. Biochem. Biophys. (1987) [Pubmed]
  13. Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. Serino, L., Reimmann, C., Baur, H., Beyeler, M., Visca, P., Haas, D. Mol. Gen. Genet. (1995) [Pubmed]
  14. The role of salicylic acid in the induction of cell death in Arabidopsis acd11. Brodersen, P., Malinovsky, F.G., Hématy, K., Newman, M.A., Mundy, J. Plant Physiol. (2005) [Pubmed]
  15. Nucleotide sequence of Escherichia coli isochorismate synthetase gene entC and evolutionary relationship of isochorismate synthetase and other chorismate-utilizing enzymes. Ozenberger, B.A., Brickman, T.J., McIntosh, M.A. J. Bacteriol. (1989) [Pubmed]
  16. Anaerobic biosynthesis of enterobactin Escherichia coli: regulation of entC gene expression and evidence against its involvement in menaquinone (vitamin K2) biosynthesis. Kwon, O., Hudspeth, M.E., Meganathan, R. J. Bacteriol. (1996) [Pubmed]
  17. Bulk purification of isochorismic acid by low-pressure octadecyl (C18) reverse-phase liquid chromatography. Seeger, J.W., Bentley, R. Anal. Biochem. (1991) [Pubmed]
  18. Properties of isochorismate hydroxymutase from Flavobacterium K3-15. Schaaf, P.M., Heide, L.E., Leistner, E.W., Tani, Y., Karas, M., Deutzmann, R. J. Nat. Prod. (1993) [Pubmed]
  19. Bacterial production of transdihydroxycyclohexadiene carboxylates by metabolic pathway engineering. Müller, R., Breuer, M., Wagener, A., Schmidt, K., Leistner, E. Microbiology (Reading, Engl.) (1996) [Pubmed]
  20. Induction of resistance to Verticillium dahliae in Arabidopsis thaliana by the biocontrol agent K-165 and pathogenesis-related proteins gene expression. Tjamos, S.E., Flemetakis, E., Paplomatas, E.J., Katinakis, P. Mol. Plant Microbe Interact. (2005) [Pubmed]
  21. Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus. van Tegelen, L.J., Moreno, P.R., Croes, A.F., Verpoorte, R., Wullems, G.J. Plant Physiol. (1999) [Pubmed]
  22. Vitamin K (menaquinone) biosynthesis in bacteria: high-performance liquid chromatographic assay of the overall synthesis of o-succinylbenzoic acid and of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase. Popp, J.L., Berliner, C., Bentley, R. Anal. Biochem. (1989) [Pubmed]
  23. Immobilization of isochorismate hydroxymutase. Comparison of native versus immobilized enzyme. Schaaf, P.M., Heide, L.E., Leistner, E.W., Tani, Y., el-Olemy, M.M. J. Nat. Prod. (1993) [Pubmed]
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