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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Neurokinin B     (3S)-3-amino-3-[[(1S)-1- [[(1S)-1-[[(1S)-1...

Synonyms: Tachykinin-3, AC1NSKET, CHEMBL437797, CHEBI:166050, DNC004401, ...
 
 
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Disease relevance of Neurokinin B

  • The increases in NK-3R mRNA in the cerebellum point to the development of receptor supersensitivity and suggest a functional role of NKB in this animal model of epilepsy [1].
 

High impact information on Neurokinin B

  • In the presence of epithelium, the sensitivity of airway smooth muscle to tachykinins was decreased, and the concentration response curves to tachykinins were shifted rightward by 30-fold for SP, 9-fold for NKA, and 5-fold for NKB [2].
  • These data, combined with the induction of Fos in medial preoptic and arcuate neurons, strongly support the hypothesis that NKB neurons play a role in the regulation of gonadotropin secretion [3].
  • In this study we investigated mRNA levels encoding the receptor for NKB, the neurokinin-3 receptor (NK-3R), after limbic seizures induced by kainic acid (KA) in the rat [1].
  • Marked changes in the expression of the tachykinin peptide neurokinin B (NKB) have been recently observed in animal models of epilepsy [1].

References

  1. Kainic acid induced seizures cause a marked increase in the expression of neurokinin-3 receptor mRNA in the rat cerebellum. Röder, C., Bellmann, R., McCarson, K.E., Krause, J.E., Sperk, G. Neurosci. Lett. (1994) [Pubmed]
  2. Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction. Grandordy, B.M., Frossard, N., Rhoden, K.J., Barnes, P.J. Mol. Pharmacol. (1988) [Pubmed]
  3. Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus. Sandoval-Guzmán, T., Rance, N.E. Brain Res. (2004) [Pubmed]
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