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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AC1NSTSR     7-[[(8aS)-2,5,5,8a- tetramethyl-6-oxo-4,4a...

Synonyms:
 
 
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Disease relevance of Conferone

  • The present study shows that conferone, a sesquiterpene coumarin ether isolated for the first time from Ferula schtschurowskiana, endemic in Uzbekistan, enhances the cell toxicity of vinblastine (VBL) in MDR1-transfected Madin-Darby canine kidney (MDCK-MDR1) cells [1].
  • Collectively, our findings identify conferone as a powerful modulator of Pgp transport and a promising molecule for the treatment of MDR malignancies and leishmaniasis [1].
 

High impact information on Conferone

  • However, the strict specificity of conferone to this efflux pump has to be demonstrated in cell lines expressing other protein transporters [1].

References

 
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