Disease relevance of estriol

• In comparison with 11 control mothers, only E3 was significantly different (10.7 +/- 3.0 ng/ml SEM in mothers with IUGR fetuses versus 25.0 +/- 4.9 in control mothers p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)[1]
• The aim of this study was to estimate local intra-tumoral and circulating levels of Estrone (E1), Estrone Sulfate (E1S), Estradiol (E2), Estriol (E3), and Testosterone (T) in 33 pre- and postmenopausal women with primary breast cancer in comparison to 12 pre- and postmenopausal women with benign breast tumors [2].

High impact information on estriol

• Measurement of E1C in both urine and feces was most useful for early pregnancy diagnosis, while E3 was of value in confirming pregnancy and assessing fetal viability [3].
• Both the vaginally delivered and cesarean section delivered IUGR infants had umbilical venous E3 levels significantly lower than in their control groups (70 +/- 10 ng/ml SEM versus 144 +/- 10, p less than 0.001, and 46 +/- 11 ng/ml SEM versus 136 +/- 23, p less than .01, respectively) [1].
• E3 was the only estrogen detected from the incubate of 16 alpha-OHT with the microsomes and NADPH, while 16 alpha-OHA gave 16 alpha-OHE1 and E3 under the same conditions [4].
• The estrogens produced by human placental microsomes, estriol (E3) and 16 alpha-hydroxyestrone (16 alpha-OHE1), were simultaneously detected in quantities as low as 1-2 ng using 3-methoxy-1,3,5(10)-estratriene-2, 16 alpha,17 beta-triol as an internal standard [4].
• Estradiol-17 beta (E2) and estriol (E3), as well as triphenylethylene (TPE) compounds, CI-628 and clomiphene citrate (CC), were used to characterize Phase I and Phase II responses in uterine preparation for implantation in the mouse [5].

Chemical compound and disease context of estriol

• The goal of the study was the determination of the relative roles of the placenta and the fetus in causing low serum estriol (E3) levels in women bearing fetuses with intrauterine growth retardation (IUGR) [1].

Gene context of estriol

• E3 was inferior to E2 in this response [5].

References