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Chemical Compound Review

Glycycoumarin     3-(2,4-dihydroxyphenyl)-7- hydroxy-5...

Synonyms: CHEMBL1223642, CHEBI:69087, CHEBI:790090, AC1NSW00, LMPK12160018, ...
 
 
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High impact information on Glycycoumarin

  • Some prenylflavonoids including glycycoumarin, glycyrin, dehydroglyasperin C and dehydroglyasperin D, a newly found compound, were identified as active compounds with PPAR-gamma ligand-binding activity in the nonaqueous fraction of licorice [1].
  • Previously, we have reported the isolation of glycycoumarin as a potent antispasmodic with an IC(50) value of 2.93+/-0.94 muM for carbamylcholine (CCh)-induced contraction of mouse jejunum from an aqueous extract of Glycyrrhizae Radix (licorice), and clarified that its mechanism of action involves inhibition of phosphodiesterase 3 [2].
  • These results indicate that glycycoumarin has an inhibitory effect on smooth muscle contraction induced by various types of stimulants through the inhibition of PDEs, especially isozyme 3, followed by the accumulation of intracellular cAMP [3].
  • Pharmaceutical Evaluation of Cultivated Glycyrrhiza uralensis Roots in Comparison of Their Antispasmodic Activity and Glycycoumarin Contents with Those of Licorice [4].
  • HPLC analysis of the roots indicated that species-specific flavonoids, glabridin and glycycoumarin, were detected in the roots of G. glabra and G. uralensis, respectively, but neither flavonoid was detected in underground parts of the intermediate-types [5].
 

Anatomical context of Glycycoumarin

  • In this paper we investigated the effects and the action mechanism of glycycoumarin on the contraction of mouse jejunum [3].

References

  1. A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. Mae, T., Kishida, H., Nishiyama, T., Tsukagawa, M., Konishi, E., Kuroda, M., Mimaki, Y., Sashida, Y., Takahashi, K., Kawada, T., Nakagawa, K., Kitahara, M. J. Nutr. (2003) [Pubmed]
  2. Isoliquiritigenin, one of the antispasmodic principles of glycyrrhiza ularensis roots, acts in the lower part of intestine. Sato, Y., He, J.X., Nagai, H., Tani, T., Akao, T. Biol. Pharm. Bull. (2007) [Pubmed]
  3. Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. Sato, Y., Akao, T., He, J.X., Nojima, H., Kuraishi, Y., Morota, T., Asano, T., Tani, T. Journal of ethnopharmacology. (2006) [Pubmed]
  4. Pharmaceutical Evaluation of Cultivated Glycyrrhiza uralensis Roots in Comparison of Their Antispasmodic Activity and Glycycoumarin Contents with Those of Licorice. Nagai, H., Yamamoto, Y., Sato, Y., Akao, T., Tani, T. Biol. Pharm. Bull. (2006) [Pubmed]
  5. Field survey of Glycyrrhiza plants in Central Asia (1). Characterization of G. uralensis, G. glabra and the putative intermediate collected in Kazakhstan. Hayashi, H., Hattori, S., Inoue, K., Sarsenbaev, K., Ito, M., Honda, G. Biol. Pharm. Bull. (2003) [Pubmed]
 
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