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Chemical Compound Review:

AG-G-97137 4-[(6E)-3,7,11- trimethyldodeca-1,6,10...

Synonyms: NSC-692990, NSC692990, AC1NS1P3, 74683-11-7, 4-Nerolidylcatechol

Desmarchelier, C. et al., Núñez, V. et al., Ropke, C.D. et al., Mongelli, E. et al.

Ropke, da Silva, Kera, Miranda, de Almeida, Sawada, Barros,

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High impact information on AIDS003906

The in vitro inhibition of MMP-2 and MMP-9 was measured by gelatin zymography in the presence of different concentrations of P. umbellata extract, as well as in the presence of its isolated active principle 4-nerolidylcatechol (4-NC) [1].
Bioactivity-guided fractionation of the leaf methanolic extract of P. peltata (Piperaceae), using the brine shrimp lethality test, led to the isolation of catechol derivative 4-nerolidylcatechol (4-NC) [2].
4-Nerolidylcatechol from Pothomorphe spp. scavenges peroxyl radicals and inhibits Fe(II)-dependent DNA damage [3].
The total reactive antioxidant potential (TRAP) and total antioxidant reactivity (TAR) of 4-nerolidylcatechol (4-NC) and methanolic extracts of Pothomorphe umbellata and P. peltata were determined by monitoring the intensity of luminol enhanced chemiluminescence by peroxyl radicals derived from thermolysis of 2,2'-azobis(2-amidinopropane) [3].
The enzyme activity of B. asper myotoxin I was completely inhibited by 4-nerolidylcatechol at an inhibitor:toxin ratio of 10:1 (wt/wt) with an IC50 of approximately 1mM [4].

Analytical, diagnostic and therapeutic context of AIDS003906

In addition, 4-nerolidylcatechol inhibited representatives of groups I and III of PLA(2)s. Its preincubation with Bothrops myotoxins significantly reduced their myotoxic and edema-inducing activities in animal experiments [4].

References

In Vitro and In Vivo Inhibition of Skin Matrix Metalloproteinases by Pothomorphe umbellata Root Extract. Ropke, C.D., da Silva, V.V., Kera, C.Z., Miranda, D.V., de Almeida, R.L., Sawada, T.C., Barros, S.B. Photochem. Photobiol. (2006) [Pubmed]
Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity. Mongelli, E., Romano, A., Desmarchelier, C., Coussio, J., Ciccia, G. Planta Med. (1999) [Pubmed]
4-Nerolidylcatechol from Pothomorphe spp. scavenges peroxyl radicals and inhibits Fe(II)-dependent DNA damage. Desmarchelier, C., Barros, S., Repetto, M., Latorre, L.R., Kato, M., Coussio, J., Ciccia, G. Planta Med. (1997) [Pubmed]
Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle. Núñez, V., Castro, V., Murillo, R., Ponce-Soto, L.A., Merfort, I., Lomonte, B. Phytochemistry (2005) [Pubmed]

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