Disease relevance of morantel

• Observations on parasitic gastroenteritis and bronchitis in grazing calves: effect of low level feed incorporation of morantel in early season [1].
• The potential of fumarate reductase as a therapeutic target against the human pathogen Helicobacter pylori was investigated by studying the cytotoxicity of morantel, oxantel, and thiabendazole, known to inhibit the enzyme in parasitic worms [2].
• Studies on the control of bovine ostertagiasis using a morantel sustained release bolus [3].
• Conubial dermatitis from Morantel [4].
• Morantel sustained release bolus: a new approach for the control of trichostrongylosis in Austrian cattle [5].

High impact information on morantel

• Resonantly enhanced SHG adsorption isotherm measurements carried out at the silica/water interface between 6 x 10(-7) and 5 x 10(-5) M morantel concentration result in a free energy of adsorption of 42(2) kJ/mol at pH 7 [6].
• In addition, the high mobility of morantel in silica-rich soil environments could lead to developing increased interaction of this antibiotic with target organisms, which could respond by increased drug resistance [6].
• 1. We have investigated activation and block, by the tetrahydropyrimidine anthelmintic, morantel, of nicotinic-acetylcholine receptor (AChR) currents in membrane vesicles isolated from somatic muscle cells of the nematode parasite Ascaris suum [7].
• The in vitro and in vivo metabolism of morantel in cattle and toxicology species [8].
• Closantel and ivermectin were 100% effective against Haemonchus contortus while fenbendazole and morantel reduced faecal egg counts by 87 and 29%, respectively [9].

Chemical compound and disease context of morantel

• In an experiment carried out in 1981 and 1982, the effect of the use of a morantel sustained release bolus (Paratect bolus) on the weight gain and a number of parasitological parameters of cattle was studied [10].
• During the grazing season one group had received fenbendazole at fortnightly intervals to suppress trichostrongyle infections, one received a morantel sustained release bolus before grazing to limit trichostrongyle contamination of the pasture, and the control group was only medicated when heavy infections caused clinical type 1 ostertagiasis [11].
• Levimisole at a dose of 6.4 mg/kg body weight, morantel at 4.4 mg/kg and 8.8 mg/kg, naphthalophos at 6.25 mg/kg and 12.5 mg/kg, rafoxanide at 7.5 mg/kg and phenothiazine at 530 mg/kg were 98% or more effective in removing adult infections of benzimidazole resistant H. contortus [12].

Biological context of morantel

• Epidemiology and control of gastrointestinal parasitism in lactating, grazing adult dairy cows using a morantel sustained release bolus [13].
• Alkaline hydrolysis of tissue liberates and converts pyrantel- and morantel-related residues to 3-(2-thienyl)-acrylic acid (TAA) and 3-(3-methyl-2-thienyl)-acrylic acid (MTAA), respectively [14].
• Pharmacodynamics, pharmacokinetics and faecal persistence of morantel in cattle and goats [15].
• The IC50 values ranged from 0.012 microM (IVM) to 2.96 microM (MRT) [16].
• Morantel did not affect the fecundity of adult O. ostertagi surviving treatment 18 days after infection which had similar average numbers of eggs in their uteri (range 13.4 +/- 0.73-16.8 +/- 0.98) as did parasites from control animals (range 12.0 +/- 0.70-13.6 +/- 0.66) [15].

Anatomical context of morantel

• The morantel Cmax, Css, area under the zero (AUC) and first moment (AUMC) of the concentration-time curve were significantly higher (P less than 0.01) in feces than in other compartments [17].

Associations of morantel with other chemical compounds

• Resistance of Trichostrongylus colubriformis to levamisole and morantel: differences in relation to selection history [18].
• The susceptibility of Ostertagia and Cooperia to morantel tartrate after extended exposure to the morantel sustained release bolus [19].
• Detailed dose response studies showed that both T colubriformis and Ostertagia sp were highly resistant to levamisole and morantel with low level resistance to thiabendazole [20].
• The occurrence of anthelmintic resistance in Trochostrongylus colubriformis and resistance to morantel are reported for the first time in New Zealand. In two controlled anthelmintic trials with experimentally infected sheep, morantel citrate at either 8.8 mg/kg or 10 mg/kg had no effect on worm burden [21].
• The method is based on hydrolysis of the N-methyl-tetrahydropyrimidine portion of morantel and its metabolites to N-methyl-1,3-propanediamine, and converting the diamine to an N,N-bis-(2-nitro-4-trifluoromethylphenyl) derivative [22].

Analytical, diagnostic and therapeutic context of morantel

• Similarly, morantel-resistant and susceptible strains of T. colubriformis could not be differentiated in this bioassay [23].
• Each of the animals of one group had received a morantel sustained release bolus, the other control group remained untreated [24].
• The introduction of a morantel sustained release bolus and/or a trickle infection had no effect on the high degree of protection engendered by the vaccination [25].
• Determination of morantel-related residues in bovine milk by electron capture gas chromatography [22].
• Monitoring of morantel levels in digestive contents by high performance liquid chromatography [26].

References