Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Supermutagen (1Z,7Z)-1,8-didiazonioocta- 1,7-diene-2,7...

Synonyms: DAB (mutagen), STOCK3S-01608, AC1NSE41, LS-97900, STL334255, ...

This record was replaced with 6857851.

Searle, A.G. et al., Rinchik, E.M. et al., Grosse, J. et al.

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Disease relevance of Supermutagen

Useful methods of accelerating the production of mouse models of human hereditary disease include (1) use of a supermutagen, such as ethylnitrosourea (ENU), (2) targeted mutagenesis involving ES cells, and (3) use of gene transfer techniques, with production of 'knockout mutations' [1].

High impact information on Supermutagen

An interval of mouse chromosome (Chr) 7 surrounding the albino (Tyr; c) locus, and corresponding to a long 6- to 11-cM Tyr deletion, has been the target of a large-scale mutagenesis screen with the chemical supermutagen N-ethyl-N-nitrosourea (ENU) [2].
Chemical random mutagenesis techniques with the germ line supermutagen N-ethyl-N-nitrosourea (ENU) have been established to provide comprehensive collections of mouse models, which were then mined and analyzed in phenotype-driven studies [3].

References

Mouse homologues of human hereditary disease. Searle, A.G., Edwards, J.H., Hall, J.G. J. Med. Genet. (1994) [Pubmed]
N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations. Rinchik, E.M., Carpenter, D.A. Genetics (1999) [Pubmed]
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors. Grosse, J., Tarnow, P., Römpler, H., Schneider, B., Sedlmeier, R., Huffstadt, U., Korthaus, D., Nehls, M., Wattler, S., Schöneberg, T., Biebermann, H., Augustin, M. Physiol. Genomics (2006) [Pubmed]

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