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Chemical Compound Review:

AC1NSP2Z (1Z,4Z,8Z)-cyclododeca-1,4,8- triene

Synonyms: LS-55971, 25167-63-9, EINECS 248-206-1, 1,4,8-Cyclododecatriene, (E,E,Z)-Cyclododecatriene, ...

Davis, J.W. et al., Sparnins, V.L. et al., Munley, S.M. et al., Bamberger, J.R. et al.

Munley, Kelly, Kennedy, Davis, Gonsior, Markham, Friederich, Hunziker, Ariano,

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Disease relevance of EINECS 248-206-1

The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats [1].

High impact information on EINECS 248-206-1

Using a combination of high performance liquid chromatography atmospheric pressure photoionization mass spectrometry and gas chromatography electron impact ionization mass spectrometry these metabolites were identified as tetrabromocyclododecene, dibromocyclododecadiene, and cyclododecatriene [2].
Thus, feeding 1,5,9-trans,trans,cis- cyclododecatriene increased this activity almost 4-fold in the livers and the intestinal mucosa of experimental animals [3].

Biological context of EINECS 248-206-1

Inhalation toxicity of cyclododecatriene in rats [4].

References

Evaluation of the potential developmental toxicity of cyclododecatriene (CDDT). Munley, S.M., Kelly, D.P., Kennedy, G.L. Drug and chemical toxicology. (2003) [Pubmed]
Biodegradation and product identification of [14C]hexabromocyclododecane in wastewater sludge and freshwater aquatic sediment. Davis, J.W., Gonsior, S.J., Markham, D.A., Friederich, U., Hunziker, R.W., Ariano, J.M. Environ. Sci. Technol. (2006) [Pubmed]
Effects of cyclic 12-, 8-, and 6-carbon compounds on glutathione S-transferase activity. Sparnins, V.L., Lam, L.K., Wattenberg, L.W. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
Inhalation toxicity of cyclododecatriene in rats. Bamberger, J.R., Scott, R.S., Kelly, D.P., Kennedy, G.L., Elliott, G.S. Drug and chemical toxicology. (1999) [Pubmed]

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