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Chemical Compound Review:

AC1NTIE8 N'-[(Z)-[5-(hydroxymethyl)-2- methyl-3-oxo...

Synonyms: CHEMBL103111, NSC-77674, STOCK1S-06278, NSC77674, STL321530, ...

Partanen, A.M. et al., Buss, J.L. et al., Hermes-Lima, M. et al., Bakkeren, D.L. et al., Buss, J.L. et al.

Hermes-Lima, Nagy, Ponka, Schulman,

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Disease relevance of NSC 77674

Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells [1].

High impact information on NSC 77674

The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against *OH-mediated strand breaks [2].
The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues [3].
A lipophilic iron chelator, pyridoxal isonicotinoyl hydrazone (PIH), can replace transferrin and support tooth morphogenesis in organ culture [4].
However, endosomes did release iron on incubation with the iron chelator pyridoxal-isonicotinoyl hydrazone [5].

References

Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells. Buss, J.L., Arduini, E., Shephard, K.C., Ponka, P. Biochem. Pharmacol. (2003) [Pubmed]
The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against *OH-mediated strand breaks. Hermes-Lima, M., Nagy, E., Ponka, P., Schulman, H.M. Free Radic. Biol. Med. (1998) [Pubmed]
The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues. Buss, J.L., Neuzil, J., Ponka, P. Biochem. Soc. Trans. (2002) [Pubmed]
Transferrin and tooth morphogenesis: retention of transferrin by mouse embryonic teeth in organ culture. Partanen, A.M., Thesleff, I. Differentiation (1987) [Pubmed]
Release of iron from endosomes is an early step in the transferrin cycle. Bakkeren, D.L., de Jeu-Jaspars, C.M., Kroos, M.J., van Eijk, H.G. Int. J. Biochem. (1987) [Pubmed]

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